A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin
We introduced a label-free sensing system based on an array of microring resonators (MRRs) which was successfully employed for human serum albumin (HSA) detection. The sensing-ring surface was functionalized to immobilize anti-HSA, facilitating HSA binding. Our refractive index sensing system demons...
| Main Authors: | , , , , , , |
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/24/2/677 |
| _version_ | 1797339380985102336 |
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| author | Xin Chen Mingyu Li Zhaoyu Wang Kaihao Zhao Jiamei Gu Qiushun Li Jian-Jun He |
| author_facet | Xin Chen Mingyu Li Zhaoyu Wang Kaihao Zhao Jiamei Gu Qiushun Li Jian-Jun He |
| author_sort | Xin Chen |
| collection | DOAJ |
| description | We introduced a label-free sensing system based on an array of microring resonators (MRRs) which was successfully employed for human serum albumin (HSA) detection. The sensing-ring surface was functionalized to immobilize anti-HSA, facilitating HSA binding. Our refractive index sensing system demonstrates high sensitivity at 168 nm/RIU and a low limit of detection (LOD) of 63.54 ng/mL, closely comparable to current HSA detection methods. These findings confirm the potential of MRRs as biocompatible sensors for HSA detection. This system holds great promise as an innovative platform for the detection of HSA, carrying significant importance in medical diagnostics. |
| first_indexed | 2024-03-08T09:47:15Z |
| format | Article |
| id | doaj.art-fa054e19d62f46fb916ab68b11e5bd5f |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-08T09:47:15Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-fa054e19d62f46fb916ab68b11e5bd5f2024-01-29T14:18:06ZengMDPI AGSensors1424-82202024-01-0124267710.3390/s24020677A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum AlbuminXin Chen0Mingyu Li1Zhaoyu Wang2Kaihao Zhao3Jiamei Gu4Qiushun Li5Jian-Jun He6Department of Optical Engineering, School of Opto-Electronic Engineering, Changchun University of Science and Technology, Changchun 130022, ChinaDepartment of Optical Engineering, School of Opto-Electronic Engineering, Changchun University of Science and Technology, Changchun 130022, ChinaDepartment of Optical Engineering, School of Opto-Electronic Engineering, Changchun University of Science and Technology, Changchun 130022, ChinaDepartment of Optical Engineering, School of Opto-Electronic Engineering, Changchun University of Science and Technology, Changchun 130022, ChinaState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaDezhou Research Institute, Qilu University of Technology (Shandong Academy of Sciences), Dezhou 253084, ChinaState Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, ChinaWe introduced a label-free sensing system based on an array of microring resonators (MRRs) which was successfully employed for human serum albumin (HSA) detection. The sensing-ring surface was functionalized to immobilize anti-HSA, facilitating HSA binding. Our refractive index sensing system demonstrates high sensitivity at 168 nm/RIU and a low limit of detection (LOD) of 63.54 ng/mL, closely comparable to current HSA detection methods. These findings confirm the potential of MRRs as biocompatible sensors for HSA detection. This system holds great promise as an innovative platform for the detection of HSA, carrying significant importance in medical diagnostics.https://www.mdpi.com/1424-8220/24/2/677array of microring resonatorslabel-free detectionsurface functionalizationHSA protein |
| spellingShingle | Xin Chen Mingyu Li Zhaoyu Wang Kaihao Zhao Jiamei Gu Qiushun Li Jian-Jun He A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin Sensors array of microring resonators label-free detection surface functionalization HSA protein |
| title | A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin |
| title_full | A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin |
| title_fullStr | A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin |
| title_full_unstemmed | A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin |
| title_short | A Label-Free Optical Biosensor Based on an Array of Microring Resonators for the Detection of Human Serum Albumin |
| title_sort | label free optical biosensor based on an array of microring resonators for the detection of human serum albumin |
| topic | array of microring resonators label-free detection surface functionalization HSA protein |
| url | https://www.mdpi.com/1424-8220/24/2/677 |
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