Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation
Background : The primo vascular system can be viewed as a circulatory system that plays a therapeutic function in regenerating the body tissue. The anti-CD3 monoclonal antibody was used as an immunotherapeutic agent to treat the novel coronavirus infection (COVID-19). Objectives: In this study, we o...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Association of Pharmacopuncture Institute
2022-02-01
|
| Series: | Journal of Acupuncture & Meridian Studies |
| Subjects: | |
| Online Access: | https://www.journal-jams.org/journal/view.html?doi=10.51507/j.jams.2022.15.1.37 |
| _version_ | 1797960236275859456 |
|---|---|
| author | Sang-Heon Choi Jong-Gu Choi Sang-Suk Lee |
| author_facet | Sang-Heon Choi Jong-Gu Choi Sang-Suk Lee |
| author_sort | Sang-Heon Choi |
| collection | DOAJ |
| description | Background : The primo vascular system can be viewed as a circulatory system that plays a therapeutic function in regenerating the body tissue. The anti-CD3 monoclonal antibody was used as an immunotherapeutic agent to treat the novel coronavirus infection (COVID-19). Objectives: In this study, we observed the effect of injecting lymph nodes with Foralumab, an anti- human CD3 epsilon therapeutic monoclonal antibody, on primo vessels. Methods : The structure and atomic stoichiometry of the antibody were determined by transmission electron microscopy and energy dispersive spectroscopy. Alcian blue dying solution was injected into the lymph nodes of the abdominal vena cava of rabbits, and the solution further flowed into the lymph vessels. Results : A primo vessel with primo nodes stained with Alcian blue was clearly visible in the lymph vessel. By injecting Foralumab into lymph nodes of rabbits with lipopolysaccharide-induced inflammation, the floating primo vessel in the lymph vessel appeared thicker and was distinctly visible. Conclusion : The observation of the primo vessel post-treated with Foralumab in the inflamed lymphatic system suggests the possibility of a functional role of the primo vascular circulatory system in pathophysiological conditions. |
| first_indexed | 2024-04-11T00:43:07Z |
| format | Article |
| id | doaj.art-fa07932544474c83b8b3e3cb3318cb01 |
| institution | Directory Open Access Journal |
| issn | 2005-2901 |
| language | English |
| last_indexed | 2024-04-11T00:43:07Z |
| publishDate | 2022-02-01 |
| publisher | Medical Association of Pharmacopuncture Institute |
| record_format | Article |
| series | Journal of Acupuncture & Meridian Studies |
| spelling | doaj.art-fa07932544474c83b8b3e3cb3318cb012023-01-06T01:41:41ZengMedical Association of Pharmacopuncture InstituteJournal of Acupuncture & Meridian Studies2005-29012022-02-01151374210.51507/j.jams.2022.15.1.37j.jams.2022.15.1.37Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced InflammationSang-Heon Choi0Jong-Gu Choi1Sang-Suk Lee2Department of Oriental Biomedical Engineering, College of Health and Medical Sciences, Sangji University, Wonju, KoreaDepartment of Oriental Biomedical Engineering, College of Health and Medical Sciences, Sangji University, Wonju, KoreaDepartment of Oriental Biomedical Engineering, College of Health and Medical Sciences, Sangji University, Wonju, KoreaBackground : The primo vascular system can be viewed as a circulatory system that plays a therapeutic function in regenerating the body tissue. The anti-CD3 monoclonal antibody was used as an immunotherapeutic agent to treat the novel coronavirus infection (COVID-19). Objectives: In this study, we observed the effect of injecting lymph nodes with Foralumab, an anti- human CD3 epsilon therapeutic monoclonal antibody, on primo vessels. Methods : The structure and atomic stoichiometry of the antibody were determined by transmission electron microscopy and energy dispersive spectroscopy. Alcian blue dying solution was injected into the lymph nodes of the abdominal vena cava of rabbits, and the solution further flowed into the lymph vessels. Results : A primo vessel with primo nodes stained with Alcian blue was clearly visible in the lymph vessel. By injecting Foralumab into lymph nodes of rabbits with lipopolysaccharide-induced inflammation, the floating primo vessel in the lymph vessel appeared thicker and was distinctly visible. Conclusion : The observation of the primo vessel post-treated with Foralumab in the inflamed lymphatic system suggests the possibility of a functional role of the primo vascular circulatory system in pathophysiological conditions.https://www.journal-jams.org/journal/view.html?doi=10.51507/j.jams.2022.15.1.37primo vessellipopolysaccharide (lps)anti-cd3monoclonal antibodyforalumablymph vessel |
| spellingShingle | Sang-Heon Choi Jong-Gu Choi Sang-Suk Lee Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation Journal of Acupuncture & Meridian Studies primo vessel lipopolysaccharide (lps) anti-cd3 monoclonal antibody foralumab lymph vessel |
| title | Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation |
| title_full | Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation |
| title_fullStr | Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation |
| title_full_unstemmed | Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation |
| title_short | Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation |
| title_sort | injection effect of anti cd3 monoclonal antibody on primo vessel in lymph vessel of rabbit with lipopolysaccharide induced inflammation |
| topic | primo vessel lipopolysaccharide (lps) anti-cd3 monoclonal antibody foralumab lymph vessel |
| url | https://www.journal-jams.org/journal/view.html?doi=10.51507/j.jams.2022.15.1.37 |
| work_keys_str_mv | AT sangheonchoi injectioneffectofanticd3monoclonalantibodyonprimovesselinlymphvesselofrabbitwithlipopolysaccharideinducedinflammation AT jongguchoi injectioneffectofanticd3monoclonalantibodyonprimovesselinlymphvesselofrabbitwithlipopolysaccharideinducedinflammation AT sangsuklee injectioneffectofanticd3monoclonalantibodyonprimovesselinlymphvesselofrabbitwithlipopolysaccharideinducedinflammation |