Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles
Copper has intrinsic antimicrobial properties. Wound dressings impregnated with cuprous oxide microparticles (hereafter termed COD) have been cleared for the management of acute and chronic wounds by the FDA and other regulatory bodies. The COD reduced the viable microbial titers of a wide spectrum...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Microbiology Research |
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| Online Access: | https://www.mdpi.com/2036-7481/13/3/29 |
| _version_ | 1797484780836618240 |
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| author | Gadi Borkow Tohar Roth Alexander Kalinkovich |
| author_facet | Gadi Borkow Tohar Roth Alexander Kalinkovich |
| author_sort | Gadi Borkow |
| collection | DOAJ |
| description | Copper has intrinsic antimicrobial properties. Wound dressings impregnated with cuprous oxide microparticles (hereafter termed COD) have been cleared for the management of acute and chronic wounds by the FDA and other regulatory bodies. The COD reduced the viable microbial titers of a wide spectrum of microbes by more than 10,000-fold (4-logs) within 3 h of exposure at 37 °C (<i>p</i> < 0.001). Similar microbial titer reductions were achieved by 3-year naturally aged COD dressings, showing the stability of the biocidal efficacy over time. The potent biocidal efficacy of the COD was maintained even after 7 daily consecutive inoculations of the dressings with ~10<sup>6</sup> CFU. COD with an adhesive contour blocked the passage of bacteria from the exterior environment to the wound bed side of the dressing even after 7 daily consecutive inoculations of different bacteria on the outer surface of the dressings. Taken together, the study demonstrates the wide spectrum potent in vitro biocidal efficacy of the cuprous oxide impregnated dressings against a wide panel of microorganisms. |
| first_indexed | 2024-03-09T23:09:22Z |
| format | Article |
| id | doaj.art-fa09fed030d945abb8b8df4269b2b209 |
| institution | Directory Open Access Journal |
| issn | 2036-7481 |
| language | English |
| last_indexed | 2024-03-09T23:09:22Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microbiology Research |
| spelling | doaj.art-fa09fed030d945abb8b8df4269b2b2092023-11-23T17:47:59ZengMDPI AGMicrobiology Research2036-74812022-06-0113336637610.3390/microbiolres13030029Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide MicroparticlesGadi Borkow0Tohar Roth1Alexander Kalinkovich2MedCu Technologies Ltd., 11 Galgalei Haplada St., Herzliya 4672200, IsraelMedCu Technologies Ltd., 11 Galgalei Haplada St., Herzliya 4672200, IsraelMedCu Technologies Ltd., 11 Galgalei Haplada St., Herzliya 4672200, IsraelCopper has intrinsic antimicrobial properties. Wound dressings impregnated with cuprous oxide microparticles (hereafter termed COD) have been cleared for the management of acute and chronic wounds by the FDA and other regulatory bodies. The COD reduced the viable microbial titers of a wide spectrum of microbes by more than 10,000-fold (4-logs) within 3 h of exposure at 37 °C (<i>p</i> < 0.001). Similar microbial titer reductions were achieved by 3-year naturally aged COD dressings, showing the stability of the biocidal efficacy over time. The potent biocidal efficacy of the COD was maintained even after 7 daily consecutive inoculations of the dressings with ~10<sup>6</sup> CFU. COD with an adhesive contour blocked the passage of bacteria from the exterior environment to the wound bed side of the dressing even after 7 daily consecutive inoculations of different bacteria on the outer surface of the dressings. Taken together, the study demonstrates the wide spectrum potent in vitro biocidal efficacy of the cuprous oxide impregnated dressings against a wide panel of microorganisms.https://www.mdpi.com/2036-7481/13/3/29copperwoundsdressingsantimicrobialbiocidal activity |
| spellingShingle | Gadi Borkow Tohar Roth Alexander Kalinkovich Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles Microbiology Research copper wounds dressings antimicrobial biocidal activity |
| title | Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles |
| title_full | Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles |
| title_fullStr | Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles |
| title_full_unstemmed | Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles |
| title_short | Wide Spectrum Potent Antimicrobial Efficacy of Wound Dressings Impregnated with Cuprous Oxide Microparticles |
| title_sort | wide spectrum potent antimicrobial efficacy of wound dressings impregnated with cuprous oxide microparticles |
| topic | copper wounds dressings antimicrobial biocidal activity |
| url | https://www.mdpi.com/2036-7481/13/3/29 |
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