Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice
It is known that lipopolysaccharide (LPS) triggers inflammatory response after intracerebroventricular (ICV) injection and elevates the expression of hepcidin through the interleukin 6/janus kinase 2/transducer and activator of the transcription 3 (IL-6/JAK2/STAT3) signaling pathway in the brain. Th...
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.649640/full |
| _version_ | 1819170624380076032 |
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| author | Fali Zhang Peng Zhao Zhongming Qian Zhongming Qian Mingkang Zhong |
| author_facet | Fali Zhang Peng Zhao Zhongming Qian Zhongming Qian Mingkang Zhong |
| author_sort | Fali Zhang |
| collection | DOAJ |
| description | It is known that lipopolysaccharide (LPS) triggers inflammatory response after intracerebroventricular (ICV) injection and elevates the expression of hepcidin through the interleukin 6/janus kinase 2/transducer and activator of the transcription 3 (IL-6/JAK2/STAT3) signaling pathway in the brain. This study was conducted to determine whether LPS ICV injection can regulate peripheral hepatic hepcidin expression and iron metabolism. Here, we studied the hepcidin expression in the liver, as well as serum iron and transferrin saturation, after LPS ICV injection. We also demonstrated the role of the IL-6/JAK2/STAT3 pathway in hepcidin expression in the livers of IL-6 knockout (IL-6–/– mice) and IL-6+/+ mice. AG490 was used to verify the effect of the IL-6/JAK2/STAT3 pathway on hepatic hepcidin expression. Our present study demonstrated that LPS ICV injection up-regulated hepatic hepcidin expression. This finding provides further evidence for highlighting the importance of the central inflammation on hepatic hepcidin expression and peripheral iron metabolism. |
| first_indexed | 2024-12-22T19:38:21Z |
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| id | doaj.art-fa0a0ca336d14e5dbef8d5ffd755e549 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-22T19:38:21Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-fa0a0ca336d14e5dbef8d5ffd755e5492022-12-21T18:14:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-04-01810.3389/fnut.2021.649640649640Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in MiceFali Zhang0Peng Zhao1Zhongming Qian2Zhongming Qian3Mingkang Zhong4Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, ChinaInstitute of Translational & Precision Medicine, Laboratory of Neuropharmacology, Nantong University, Nantong, ChinaInstitute of Translational & Precision Medicine, Laboratory of Neuropharmacology, Nantong University, Nantong, ChinaLaboratory of Neuropharmacology, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Pharmacy, Huashan Hospital, Fudan University, Shanghai, ChinaIt is known that lipopolysaccharide (LPS) triggers inflammatory response after intracerebroventricular (ICV) injection and elevates the expression of hepcidin through the interleukin 6/janus kinase 2/transducer and activator of the transcription 3 (IL-6/JAK2/STAT3) signaling pathway in the brain. This study was conducted to determine whether LPS ICV injection can regulate peripheral hepatic hepcidin expression and iron metabolism. Here, we studied the hepcidin expression in the liver, as well as serum iron and transferrin saturation, after LPS ICV injection. We also demonstrated the role of the IL-6/JAK2/STAT3 pathway in hepcidin expression in the livers of IL-6 knockout (IL-6–/– mice) and IL-6+/+ mice. AG490 was used to verify the effect of the IL-6/JAK2/STAT3 pathway on hepatic hepcidin expression. Our present study demonstrated that LPS ICV injection up-regulated hepatic hepcidin expression. This finding provides further evidence for highlighting the importance of the central inflammation on hepatic hepcidin expression and peripheral iron metabolism.https://www.frontiersin.org/articles/10.3389/fnut.2021.649640/fullAG490stat3IL-6-/-miceLPShepcidin |
| spellingShingle | Fali Zhang Peng Zhao Zhongming Qian Zhongming Qian Mingkang Zhong Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice Frontiers in Nutrition AG490 stat3 IL-6-/-mice LPS hepcidin |
| title | Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice |
| title_full | Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice |
| title_fullStr | Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice |
| title_full_unstemmed | Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice |
| title_short | Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice |
| title_sort | central nervous system inflammation induced by lipopolysaccharide up regulates hepatic hepcidin expression by activating the il 6 jak2 stat3 pathway in mice |
| topic | AG490 stat3 IL-6-/-mice LPS hepcidin |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.649640/full |
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