Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells
Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers,...
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/4083 |
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| author | Asami Nishikori Yoshito Nishimura Rei Shibata Koh-ichi Ohshima Yuka Gion Tomoka Ikeda Midori Filiz Nishimura Tadashi Yoshino Yasuharu Sato |
| author_facet | Asami Nishikori Yoshito Nishimura Rei Shibata Koh-ichi Ohshima Yuka Gion Tomoka Ikeda Midori Filiz Nishimura Tadashi Yoshino Yasuharu Sato |
| author_sort | Asami Nishikori |
| collection | DOAJ |
| description | Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been noted to induce its upregulation to propel oncogenesis. We examined AID expression in IgG4-related ophthalmic disease (IgG4-ROD; <i>n</i> = 16), marginal zone lymphoma with IgG4-positive cells (IgG4+ MZL; <i>n</i> = 11), and marginal zone lymphoma without IgG4-positive cells (IgG4- MZL; <i>n</i> = 12) of ocular adnexa using immunohistochemical staining. Immunohistochemistry revealed significantly higher AID-intensity index in IgG4-ROD and IgG4+ MZL than IgG4- MZL (<i>p</i> < 0.001 and = 0.001, respectively). The present results suggest that IgG4-RD has several specific causes of AID up-regulation in addition to inflammation, and AID may be a driver of oncogenesis in IgG4-ROD to IgG4+ MZL. |
| first_indexed | 2024-03-10T12:18:52Z |
| format | Article |
| id | doaj.art-fa0cb12b347343d18339b7a2543a4e51 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:18:52Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fa0cb12b347343d18339b7a2543a4e512023-11-21T15:41:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228408310.3390/ijms22084083Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive CellsAsami Nishikori0Yoshito Nishimura1Rei Shibata2Koh-ichi Ohshima3Yuka Gion4Tomoka Ikeda5Midori Filiz Nishimura6Tadashi Yoshino7Yasuharu Sato8Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDepartment of General Medicine, Okayama University Hospital, Okayama 700-8558, JapanDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Ophthalmology, National Hospital Organization Okayama Medical Center, Okayama 701-1192, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, JapanDivision of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, JapanImmunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been noted to induce its upregulation to propel oncogenesis. We examined AID expression in IgG4-related ophthalmic disease (IgG4-ROD; <i>n</i> = 16), marginal zone lymphoma with IgG4-positive cells (IgG4+ MZL; <i>n</i> = 11), and marginal zone lymphoma without IgG4-positive cells (IgG4- MZL; <i>n</i> = 12) of ocular adnexa using immunohistochemical staining. Immunohistochemistry revealed significantly higher AID-intensity index in IgG4-ROD and IgG4+ MZL than IgG4- MZL (<i>p</i> < 0.001 and = 0.001, respectively). The present results suggest that IgG4-RD has several specific causes of AID up-regulation in addition to inflammation, and AID may be a driver of oncogenesis in IgG4-ROD to IgG4+ MZL.https://www.mdpi.com/1422-0067/22/8/4083activation-induced cytidine deaminaseIgG4-related diseaseIgG4-positive marginal zone lymphoma |
| spellingShingle | Asami Nishikori Yoshito Nishimura Rei Shibata Koh-ichi Ohshima Yuka Gion Tomoka Ikeda Midori Filiz Nishimura Tadashi Yoshino Yasuharu Sato Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells International Journal of Molecular Sciences activation-induced cytidine deaminase IgG4-related disease IgG4-positive marginal zone lymphoma |
| title | Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells |
| title_full | Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells |
| title_fullStr | Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells |
| title_full_unstemmed | Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells |
| title_short | Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells |
| title_sort | upregulated expression of activation induced cytidine deaminase in ocular adnexal marginal zone lymphoma with igg4 positive cells |
| topic | activation-induced cytidine deaminase IgG4-related disease IgG4-positive marginal zone lymphoma |
| url | https://www.mdpi.com/1422-0067/22/8/4083 |
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