The relationship between oxidative stress and acute ischemic stroke severity and functional outcome
Abstract Background Cerebral ischemia initiates an oxidative stress response in the brain which is a composite process that involves many oxidative stress biomarkers. High levels of malondialdehyde (MDA) in patients with acute ischemic stroke had been found. The evaluation of oxidative stress in the...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-07-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41983-020-00206-y |
| _version_ | 1819277124116152320 |
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| author | Wael M. Elsayed El-Hady A. Abdel-Gawad Dalia I. A. Mesallam Tamer S. El-Serafy |
| author_facet | Wael M. Elsayed El-Hady A. Abdel-Gawad Dalia I. A. Mesallam Tamer S. El-Serafy |
| author_sort | Wael M. Elsayed |
| collection | DOAJ |
| description | Abstract Background Cerebral ischemia initiates an oxidative stress response in the brain which is a composite process that involves many oxidative stress biomarkers. High levels of malondialdehyde (MDA) in patients with acute ischemic stroke had been found. The evaluation of oxidative stress in the acute stage may contribute to improve the post ischemic stroke outcome. Objective The aim of the current study to assess MDA level, as an oxidative stress biomarker, in acute ischemic stroke on admission and its relation with stroke severity on admission and also, its relation with three months short-term outcome. Methods Forty-two patients (20 males and 22 females) with acute ischemic stroke were prospectively enrolled in follow-up cohort study. Serum MDA was measured within 24 h after admission. We studied the relationship between MDA and stroke severity and functional outcome after 3 months assessed by National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) respectively. Results Serum MDA levels correlated significantly with clinical short-term stroke outcome after 3 months (p < 0.001). Conclusion(s) These data provide evidence that the MDA (an oxidative stress biomarker) may be used as predictor for functional outcome in acute ischemic stroke. |
| first_indexed | 2024-12-23T23:51:07Z |
| format | Article |
| id | doaj.art-fa0d59d9abff43568115c29a87fc773b |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-23T23:51:07Z |
| publishDate | 2020-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-fa0d59d9abff43568115c29a87fc773b2022-12-21T17:25:24ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292020-07-015611610.1186/s41983-020-00206-yThe relationship between oxidative stress and acute ischemic stroke severity and functional outcomeWael M. Elsayed0El-Hady A. Abdel-Gawad1Dalia I. A. Mesallam2Tamer S. El-Serafy3Neurology Department, Faculty of Medicine, Zagazig UniversityNeurology Department, Faculty of Medicine, Zagazig UniversityForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig UniversityNeurology Department, Faculty of Medicine, Zagazig UniversityAbstract Background Cerebral ischemia initiates an oxidative stress response in the brain which is a composite process that involves many oxidative stress biomarkers. High levels of malondialdehyde (MDA) in patients with acute ischemic stroke had been found. The evaluation of oxidative stress in the acute stage may contribute to improve the post ischemic stroke outcome. Objective The aim of the current study to assess MDA level, as an oxidative stress biomarker, in acute ischemic stroke on admission and its relation with stroke severity on admission and also, its relation with three months short-term outcome. Methods Forty-two patients (20 males and 22 females) with acute ischemic stroke were prospectively enrolled in follow-up cohort study. Serum MDA was measured within 24 h after admission. We studied the relationship between MDA and stroke severity and functional outcome after 3 months assessed by National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) respectively. Results Serum MDA levels correlated significantly with clinical short-term stroke outcome after 3 months (p < 0.001). Conclusion(s) These data provide evidence that the MDA (an oxidative stress biomarker) may be used as predictor for functional outcome in acute ischemic stroke.http://link.springer.com/article/10.1186/s41983-020-00206-yIschemic strokeMDANIHSSmRS |
| spellingShingle | Wael M. Elsayed El-Hady A. Abdel-Gawad Dalia I. A. Mesallam Tamer S. El-Serafy The relationship between oxidative stress and acute ischemic stroke severity and functional outcome The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Ischemic stroke MDA NIHSS mRS |
| title | The relationship between oxidative stress and acute ischemic stroke severity and functional outcome |
| title_full | The relationship between oxidative stress and acute ischemic stroke severity and functional outcome |
| title_fullStr | The relationship between oxidative stress and acute ischemic stroke severity and functional outcome |
| title_full_unstemmed | The relationship between oxidative stress and acute ischemic stroke severity and functional outcome |
| title_short | The relationship between oxidative stress and acute ischemic stroke severity and functional outcome |
| title_sort | relationship between oxidative stress and acute ischemic stroke severity and functional outcome |
| topic | Ischemic stroke MDA NIHSS mRS |
| url | http://link.springer.com/article/10.1186/s41983-020-00206-y |
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