Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake?
BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a rare neuro-respiratory disorder associated with mutations of the PHOX2B gene. Patients with this disease experience severe hypoventilation during sleep and are consequently ventilator-dependent. However, they breathe almost normally...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3901646?pdf=render |
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| author | Lysandre Tremoureux Mathieu Raux Anna L Hudson Anja Ranohavimparany Christian Straus Thomas Similowski |
| author_facet | Lysandre Tremoureux Mathieu Raux Anna L Hudson Anja Ranohavimparany Christian Straus Thomas Similowski |
| author_sort | Lysandre Tremoureux |
| collection | DOAJ |
| description | BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a rare neuro-respiratory disorder associated with mutations of the PHOX2B gene. Patients with this disease experience severe hypoventilation during sleep and are consequently ventilator-dependent. However, they breathe almost normally while awake, indicating the existence of cortical mechanisms compensating for the deficient brainstem generation of automatic breathing. Current evidence indicates that the supplementary motor area plays an important role in modulating ventilation in awake normal humans. We hypothesized that the wake-related maintenance of spontaneous breathing in patients with CCHS could involve supplementary motor area. METHODS: We studied 7 CCHS patients (5 women; age: 20-30; BMI: 22.1 ± 4 kg.m(-2)) during resting breathing and during exposure to carbon dioxide and inspiratory mechanical constraints. They were compared with 8 healthy individuals. Segments of electroencephalographic tracings were selected according to ventilatory flow signal, from 2.5 seconds to 1.5 seconds after the onset of inspiration. After artefact rejection, 80 or more such segments were ensemble averaged. A slow upward shift of the EEG signal starting between 2 and 0.5 s before inspiration (pre-inspiratory potential) was considered suggestive of supplementary motor area activation. RESULTS: In the control group, pre-inspiratory potentials were generally absent during resting breathing and carbon dioxide stimulation, and consistently identified in the presence of inspiratory constraints (expected). In CCHS patients, pre-inspiratory potentials were systematically identified in all study conditions, including resting breathing. They were therefore significantly more frequent than in controls. CONCLUSIONS: This study provides a neurophysiological substrate to the wakefulness drive to breathe that is characteristic of CCHS and suggests that the supplementary motor area contributes to this phenomenon. Whether or not this "cortical breathing" can be taken advantage of therapeutically, or has clinical consequences (like competition with attentional resources) remains to be determined. |
| first_indexed | 2024-12-13T07:27:26Z |
| format | Article |
| id | doaj.art-fa107d96ea9a4a30a11ce0076d205489 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T07:27:26Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fa107d96ea9a4a30a11ce0076d2054892022-12-21T23:55:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8453410.1371/journal.pone.0084534Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake?Lysandre TremoureuxMathieu RauxAnna L HudsonAnja RanohavimparanyChristian StrausThomas SimilowskiBACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a rare neuro-respiratory disorder associated with mutations of the PHOX2B gene. Patients with this disease experience severe hypoventilation during sleep and are consequently ventilator-dependent. However, they breathe almost normally while awake, indicating the existence of cortical mechanisms compensating for the deficient brainstem generation of automatic breathing. Current evidence indicates that the supplementary motor area plays an important role in modulating ventilation in awake normal humans. We hypothesized that the wake-related maintenance of spontaneous breathing in patients with CCHS could involve supplementary motor area. METHODS: We studied 7 CCHS patients (5 women; age: 20-30; BMI: 22.1 ± 4 kg.m(-2)) during resting breathing and during exposure to carbon dioxide and inspiratory mechanical constraints. They were compared with 8 healthy individuals. Segments of electroencephalographic tracings were selected according to ventilatory flow signal, from 2.5 seconds to 1.5 seconds after the onset of inspiration. After artefact rejection, 80 or more such segments were ensemble averaged. A slow upward shift of the EEG signal starting between 2 and 0.5 s before inspiration (pre-inspiratory potential) was considered suggestive of supplementary motor area activation. RESULTS: In the control group, pre-inspiratory potentials were generally absent during resting breathing and carbon dioxide stimulation, and consistently identified in the presence of inspiratory constraints (expected). In CCHS patients, pre-inspiratory potentials were systematically identified in all study conditions, including resting breathing. They were therefore significantly more frequent than in controls. CONCLUSIONS: This study provides a neurophysiological substrate to the wakefulness drive to breathe that is characteristic of CCHS and suggests that the supplementary motor area contributes to this phenomenon. Whether or not this "cortical breathing" can be taken advantage of therapeutically, or has clinical consequences (like competition with attentional resources) remains to be determined.http://europepmc.org/articles/PMC3901646?pdf=render |
| spellingShingle | Lysandre Tremoureux Mathieu Raux Anna L Hudson Anja Ranohavimparany Christian Straus Thomas Similowski Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake? PLoS ONE |
| title | Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake? |
| title_full | Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake? |
| title_fullStr | Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake? |
| title_full_unstemmed | Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake? |
| title_short | Does the supplementary motor area keep patients with Ondine's curse syndrome breathing while awake? |
| title_sort | does the supplementary motor area keep patients with ondine s curse syndrome breathing while awake |
| url | http://europepmc.org/articles/PMC3901646?pdf=render |
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