Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients
The aim of the study was to examine the genotype-allele determination of CYP1A2 rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19. The study consists of 60 patients who were hospitalized in intensive...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-07-01
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| Series: | Balkan Journal of Medical Genetics |
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| Online Access: | https://doi.org/10.2478/bjmg-2023-0005 |
| _version_ | 1797740418598699008 |
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| author | Bozkurt I Gözler T Yüksel I Ulucan K Tarhan KN |
| author_facet | Bozkurt I Gözler T Yüksel I Ulucan K Tarhan KN |
| author_sort | Bozkurt I |
| collection | DOAJ |
| description | The aim of the study was to examine the genotype-allele determination of CYP1A2 rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19. The study consists of 60 patients who were hospitalized in intensive care or outpatient treatment due to COVID-19 in Istanbul NP Brain Hospital between 2020–2021. Genotyping was conducted by Real-Time PCR. Age (p<0.001); chronic disease (p=0.002); cardiovascular disease (p=0.004); respiratory distress (p<0.001); neurological disease (p=0.004); fatigue (p=0.048); loss of taste and smell (p=0.003); nausea/vomiting (p=0.026); intubated (p<0.001); ground glass image (p<0.001) and CYP1A2 genotypes (p<0.001) showed a statistically significant difference between patients with and without intensive care admission. According to multivariate logistic regression analysis, CYP1A2 *1A/*1C + *1C/*1C genotypes (OR:5.23 95% CI: 1.22–22.36; p=0.025), chronic disease (OR:4.68 95% CI:1.14–19.15; p=0.032) or patients at 65 years or older (OR:5.17, 95%CI:1.26–21.14; p=0.022) increased the risk of admission to the intensive care unit. According to our results, we strongly suggest considering the CYP1A2 rs2069514 and rs762551 polymorphisms as important predictors of Intensive Care Unit admission in patients with COVID-19, and we also suggest that genotype results will guide clinicians for the benefit and the efficiency of the treatment. |
| first_indexed | 2024-03-12T14:12:10Z |
| format | Article |
| id | doaj.art-fa10fb2a8e5a4e838152eb1da038602b |
| institution | Directory Open Access Journal |
| issn | 2199-5761 |
| language | English |
| last_indexed | 2024-03-12T14:12:10Z |
| publishDate | 2023-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Balkan Journal of Medical Genetics |
| spelling | doaj.art-fa10fb2a8e5a4e838152eb1da038602b2023-08-21T06:43:49ZengSciendoBalkan Journal of Medical Genetics2199-57612023-07-01261354210.2478/bjmg-2023-0005Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 PatientsBozkurt I0Gözler T1Yüksel I2Ulucan K3Tarhan KN4Department of Medical Biochemistry, Faculty of Medicine, Üsküdar University, Istanbul, TurkeyDepartment of Medical Genetics and Molecular Diagnostic Laboratory, Faculty of Medicine, Üsküdar University, Istanbul, TurkeyDepartment of Medical Genetics and Molecular Diagnostic Laboratory, Faculty of Medicine, Üsküdar University, Istanbul, TurkeyDepartment of Medical Genetics and Molecular Diagnostic Laboratory, Faculty of Medicine, Üsküdar University, Istanbul, TurkeyUskudar University NP Hospital, Istanbul, TurkeyThe aim of the study was to examine the genotype-allele determination of CYP1A2 rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19. The study consists of 60 patients who were hospitalized in intensive care or outpatient treatment due to COVID-19 in Istanbul NP Brain Hospital between 2020–2021. Genotyping was conducted by Real-Time PCR. Age (p<0.001); chronic disease (p=0.002); cardiovascular disease (p=0.004); respiratory distress (p<0.001); neurological disease (p=0.004); fatigue (p=0.048); loss of taste and smell (p=0.003); nausea/vomiting (p=0.026); intubated (p<0.001); ground glass image (p<0.001) and CYP1A2 genotypes (p<0.001) showed a statistically significant difference between patients with and without intensive care admission. According to multivariate logistic regression analysis, CYP1A2 *1A/*1C + *1C/*1C genotypes (OR:5.23 95% CI: 1.22–22.36; p=0.025), chronic disease (OR:4.68 95% CI:1.14–19.15; p=0.032) or patients at 65 years or older (OR:5.17, 95%CI:1.26–21.14; p=0.022) increased the risk of admission to the intensive care unit. According to our results, we strongly suggest considering the CYP1A2 rs2069514 and rs762551 polymorphisms as important predictors of Intensive Care Unit admission in patients with COVID-19, and we also suggest that genotype results will guide clinicians for the benefit and the efficiency of the treatment.https://doi.org/10.2478/bjmg-2023-0005covid-19prognosishypoxiacyp1a2polymorphism |
| spellingShingle | Bozkurt I Gözler T Yüksel I Ulucan K Tarhan KN Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients Balkan Journal of Medical Genetics covid-19 prognosis hypoxia cyp1a2 polymorphism |
| title | Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients |
| title_full | Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients |
| title_fullStr | Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients |
| title_full_unstemmed | Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients |
| title_short | Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients |
| title_sort | prognostic value of cyp1a2 rs2069514 and rs762551 polymorphisms in covid 19 patients |
| topic | covid-19 prognosis hypoxia cyp1a2 polymorphism |
| url | https://doi.org/10.2478/bjmg-2023-0005 |
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