Synthesis and Structure–Activity Relationship Studies of Pyrido [1,2-<i>e</i>]Purine-2,4(<i>1H,3H</i>)-Dione Derivatives Targeting <i>Flavin-Dependent Thymidylate Synthase</i> in <i>Mycobacterium tuberculosis</i>

Synthesis and Structure–Activity Relationship Studies of Pyrido [1,2-<i>e</i>]Purine-2,4(<i>1H,3H</i>)-Dione Derivatives Targeting <i>Flavin-Dependent Thymidylate Synthase</i> in <i>Mycobacterium tuberculosis</i>

In 2002, a new class of thymidylate synthase (TS) involved in the de novo synthesis of dTMP named <i>Flavin-Dependent Thymidylate Synthase</i> (<i>FDTS</i>) encoded by the <i>thyX</i> gene was discovered; <i>FDTS</i> is present only in 30% of prokaryot...

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Bibliographic Details
Main Authors: Nicolas G. Biteau, Vincent Roy, Cyril Nicolas, Hubert F. Becker, Jean-Christophe Lambry, Hannu Myllykallio, Luigi A. Agrofoglio
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
flavin-dependent thymidylate synthase
pyrido[1,2-<i>e</i>]purine-2,4(1<i>H</i>,3<i>H</i>)-dione analogues
structure-activity relationship
sonogashira and Suzuki-Miyaura cross-coupling
Online Access:https://www.mdpi.com/1420-3049/27/19/6216

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https://www.mdpi.com/1420-3049/27/19/6216

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