Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy
Diabetic neuropathy is one of the major complications of diabetes, and it increases morbidity and mortality in patients with both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Because the autonomic nervous system, for example, parasympathetic axons, has a diffuse and wide dist...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2015-12-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-461.pdf |
| _version_ | 1818011242579623936 |
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| author | Heung Yong Jin Hong Sun Baek Tae Sun Park |
| author_facet | Heung Yong Jin Hong Sun Baek Tae Sun Park |
| author_sort | Heung Yong Jin |
| collection | DOAJ |
| description | Diabetic neuropathy is one of the major complications of diabetes, and it increases morbidity and mortality in patients with both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Because the autonomic nervous system, for example, parasympathetic axons, has a diffuse and wide distribution, we do not know the morphological changes that occur in autonomic neural control and their exact mechanisms in diabetic patients with diabetic autonomic neuropathy (DAN). Although the prevalence of sympathetic and parasympathetic neuropathy is similar in T1DM versus T2DM patients, sympathetic nerve function correlates with parasympathetic neuropathy only in T1DM patients. The explanation for these discrepancies might be that parasympathetic nerve function was more severely affected among T2DM patients. As parasympathetic nerve damage seems to be more advanced than sympathetic nerve damage, it might be that parasympathetic neuropathy precedes sympathetic neuropathy in T2DM, which was Ewing's concept. This could be explained by the intrinsic morphologic difference. Therefore, the morphological changes in the sympathetic and parasympathetic nerves of involved organs in T1DM and T2DM patients who have DAN should be evaluated. In this review, evaluation methods for morphological changes in the epidermal nerves of skin, and the intrinsic nerves of the stomach will be discussed. |
| first_indexed | 2024-04-14T06:05:13Z |
| format | Article |
| id | doaj.art-fa16b5a0f31c4d6e94d9838d8e5a4ba8 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-14T06:05:13Z |
| publishDate | 2015-12-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-fa16b5a0f31c4d6e94d9838d8e5a4ba82022-12-22T02:08:33ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872015-12-0139646146710.4093/dmj.2015.39.6.46114722Morphologic Changes in Autonomic Nerves in Diabetic Autonomic NeuropathyHeung Yong JinHong Sun BaekTae Sun ParkDiabetic neuropathy is one of the major complications of diabetes, and it increases morbidity and mortality in patients with both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Because the autonomic nervous system, for example, parasympathetic axons, has a diffuse and wide distribution, we do not know the morphological changes that occur in autonomic neural control and their exact mechanisms in diabetic patients with diabetic autonomic neuropathy (DAN). Although the prevalence of sympathetic and parasympathetic neuropathy is similar in T1DM versus T2DM patients, sympathetic nerve function correlates with parasympathetic neuropathy only in T1DM patients. The explanation for these discrepancies might be that parasympathetic nerve function was more severely affected among T2DM patients. As parasympathetic nerve damage seems to be more advanced than sympathetic nerve damage, it might be that parasympathetic neuropathy precedes sympathetic neuropathy in T2DM, which was Ewing's concept. This could be explained by the intrinsic morphologic difference. Therefore, the morphological changes in the sympathetic and parasympathetic nerves of involved organs in T1DM and T2DM patients who have DAN should be evaluated. In this review, evaluation methods for morphological changes in the epidermal nerves of skin, and the intrinsic nerves of the stomach will be discussed.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-461.pdfAutonomic neuropathyAutonomic pathwaysDiabetesMorphology |
| spellingShingle | Heung Yong Jin Hong Sun Baek Tae Sun Park Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy Diabetes & Metabolism Journal Autonomic neuropathy Autonomic pathways Diabetes Morphology |
| title | Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy |
| title_full | Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy |
| title_fullStr | Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy |
| title_full_unstemmed | Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy |
| title_short | Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy |
| title_sort | morphologic changes in autonomic nerves in diabetic autonomic neuropathy |
| topic | Autonomic neuropathy Autonomic pathways Diabetes Morphology |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-39-461.pdf |
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