Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design
Parabens are used as preservatives in sanitizers and cosmetic products causing environmental concern, because presented potential as endocrine disrupters. Among these compounds, the most used are methylparaben and propylparaben. Thus, a study was proposed to evaluate the interaction between differe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Mato Grosso do Sul
2023-10-01
|
| Series: | Orbital: The Electronic Journal of Chemistry |
| Subjects: | |
| Online Access: | https://trilhasdahistoria.ufms.br/index.php/orbital/article/view/17993 |
| _version_ | 1797660280045436928 |
|---|---|
| author | Estela Moraes Nolasco João Vitor dos Santos da Silva João Vitor Vieira de Paula Fábio Luciano Caldas da Silva Maicon Matos Leitão Alessandra Silveira Antunes Araújo Andreia de Oliveira Massulo Amilcar Machulek Jr. LUCAS DE MELO DA SILVA |
| author_facet | Estela Moraes Nolasco João Vitor dos Santos da Silva João Vitor Vieira de Paula Fábio Luciano Caldas da Silva Maicon Matos Leitão Alessandra Silveira Antunes Araújo Andreia de Oliveira Massulo Amilcar Machulek Jr. LUCAS DE MELO DA SILVA |
| author_sort | Estela Moraes Nolasco |
| collection | DOAJ |
| description |
Parabens are used as preservatives in sanitizers and cosmetic products causing environmental concern, because presented potential as endocrine disrupters. Among these compounds, the most used are methylparaben and propylparaben. Thus, a study was proposed to evaluate the interaction between different concentrations (mmol L-1) of the variables methylparaben [MP] and propylparaben [PP], against the acute toxicity of the microcrustacean Artemia salina (A. salina) and Allium cepa (A. cepa) applying the 22 factorial design with an added center point. Responses were used: percent A. salina mortality (% mortality), A. cepa root growth inhibition (% root inhibition) and mitotic index (%MI). For A. salina, after 72 hours of exposure with the combination of concentration ([MP] and [PP] = 0.8 mmol L−1) caused an 80% mortality. While, A. cepa a high cytotoxicity was observed with the mixture of Parabens, exhibiting 72.3% root growth inhibition at [MP] = 1.2 mmol L-1 with [PP] = 1.2 mmol L-1. In contrast, for response %MI at [MP] = 0.3 mmol L-1 with [PP] = 0.3 mmol L-1, 2.5 %MI with 36% inhibition. In this context, parabens demonstrated high toxicity for A. salina and cytotoxicity for A. cepa, based on the interaction with the effect of the concentrations.
|
| first_indexed | 2024-03-11T18:28:29Z |
| format | Article |
| id | doaj.art-fa173946b9104f0291ca13db7fde49b0 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-03-11T18:28:29Z |
| publishDate | 2023-10-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-fa173946b9104f0291ca13db7fde49b02023-10-13T15:01:17ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282023-10-0115310.17807/orbital.v15i3.17993Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental DesignEstela Moraes Nolasco0João Vitor dos Santos da Silva1João Vitor Vieira de Paula2Fábio Luciano Caldas da Silva3Maicon Matos Leitão4Alessandra Silveira Antunes Araújo5Andreia de Oliveira Massulo6Amilcar Machulek Jr.7LUCAS DE MELO DA SILVA8Centro Universitário Unigran CapitalCentro Universitário Unigran CapitalCentro Universitário Unigran CapitalCentro Universitário Unigran CapitalCentro Universitário Unigran CapitalCentro Universitário Unigran CapitalCentro Universitário Unigran CapitalUniversidade Federal de Mato Grosso do SulCentro Universitário Unigran Capital Parabens are used as preservatives in sanitizers and cosmetic products causing environmental concern, because presented potential as endocrine disrupters. Among these compounds, the most used are methylparaben and propylparaben. Thus, a study was proposed to evaluate the interaction between different concentrations (mmol L-1) of the variables methylparaben [MP] and propylparaben [PP], against the acute toxicity of the microcrustacean Artemia salina (A. salina) and Allium cepa (A. cepa) applying the 22 factorial design with an added center point. Responses were used: percent A. salina mortality (% mortality), A. cepa root growth inhibition (% root inhibition) and mitotic index (%MI). For A. salina, after 72 hours of exposure with the combination of concentration ([MP] and [PP] = 0.8 mmol L−1) caused an 80% mortality. While, A. cepa a high cytotoxicity was observed with the mixture of Parabens, exhibiting 72.3% root growth inhibition at [MP] = 1.2 mmol L-1 with [PP] = 1.2 mmol L-1. In contrast, for response %MI at [MP] = 0.3 mmol L-1 with [PP] = 0.3 mmol L-1, 2.5 %MI with 36% inhibition. In this context, parabens demonstrated high toxicity for A. salina and cytotoxicity for A. cepa, based on the interaction with the effect of the concentrations. https://trilhasdahistoria.ufms.br/index.php/orbital/article/view/17993ParabensArtemia salinaAllium cepaacute toxicityexperimental design |
| spellingShingle | Estela Moraes Nolasco João Vitor dos Santos da Silva João Vitor Vieira de Paula Fábio Luciano Caldas da Silva Maicon Matos Leitão Alessandra Silveira Antunes Araújo Andreia de Oliveira Massulo Amilcar Machulek Jr. LUCAS DE MELO DA SILVA Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design Orbital: The Electronic Journal of Chemistry Parabens Artemia salina Allium cepa acute toxicity experimental design |
| title | Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design |
| title_full | Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design |
| title_fullStr | Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design |
| title_full_unstemmed | Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design |
| title_short | Combined Toxicity of Methylparaben and Propylparaben in Artemia salina and Allium cepa Applying Experimental Design |
| title_sort | combined toxicity of methylparaben and propylparaben in artemia salina and allium cepa applying experimental design |
| topic | Parabens Artemia salina Allium cepa acute toxicity experimental design |
| url | https://trilhasdahistoria.ufms.br/index.php/orbital/article/view/17993 |
| work_keys_str_mv | AT estelamoraesnolasco combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT joaovitordossantosdasilva combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT joaovitorvieiradepaula combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT fabiolucianocaldasdasilva combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT maiconmatosleitao combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT alessandrasilveiraantunesaraujo combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT andreiadeoliveiramassulo combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT amilcarmachulekjr combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign AT lucasdemelodasilva combinedtoxicityofmethylparabenandpropylparabeninartemiasalinaandalliumcepaapplyingexperimentaldesign |