Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that is predominantly caused by insulin resistance or impaired insulin secretion, along with disturbances in carbohydrate, fat and protein metabolism. Various therapeutic approaches have been used to treat diabetes, including improvem...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/6/586 |
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| author | Anand-Krishna Singh Dhananjay Yadav Neha Sharma Jun-O Jin |
| author_facet | Anand-Krishna Singh Dhananjay Yadav Neha Sharma Jun-O Jin |
| author_sort | Anand-Krishna Singh |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that is predominantly caused by insulin resistance or impaired insulin secretion, along with disturbances in carbohydrate, fat and protein metabolism. Various therapeutic approaches have been used to treat diabetes, including improvement of insulin sensitivity, inhibition of gluconeogenesis, and decreasing glucose absorption from the intestines. Recently, a novel approach has emerged using dipeptidyl peptidase-IV (DPP-IV) inhibitors as a possible agent for the treatment of T2DM without producing any side effects, such as hypoglycemia and exhaustion of pancreatic β-cells. DPP-IV inhibitors improve hyperglycemic conditions by stabilizing the postprandial level of gut hormones such as glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptides, which function as incretins to help upregulate insulin secretion and β-cell mass. In this review, we summarized DPP-IV inhibitors and their mechanism of inhibition, activities of those isolated from various natural sources, and their capacity to overcome oxidative stress in disease conditions. |
| first_indexed | 2024-03-10T10:18:07Z |
| format | Article |
| id | doaj.art-fa1839f37a4245ebb0b4a6fea33f9f3e |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T10:18:07Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-fa1839f37a4245ebb0b4a6fea33f9f3e2023-11-22T00:42:06ZengMDPI AGPharmaceuticals1424-82472021-06-0114658610.3390/ph14060586Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of DiabetesAnand-Krishna Singh0Dhananjay Yadav1Neha Sharma2Jun-O Jin3Shri Vaishnav Institute of Science, Shri Vaishnav Vidyapeeth Vishwavidyalaya, Indore, Madhya Pradesh 453555, IndiaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, KoreaSchool of Life Sciences, Devi Ahilya University, Indore, Madhya Pradesh 452001, IndiaDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, KoreaType 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that is predominantly caused by insulin resistance or impaired insulin secretion, along with disturbances in carbohydrate, fat and protein metabolism. Various therapeutic approaches have been used to treat diabetes, including improvement of insulin sensitivity, inhibition of gluconeogenesis, and decreasing glucose absorption from the intestines. Recently, a novel approach has emerged using dipeptidyl peptidase-IV (DPP-IV) inhibitors as a possible agent for the treatment of T2DM without producing any side effects, such as hypoglycemia and exhaustion of pancreatic β-cells. DPP-IV inhibitors improve hyperglycemic conditions by stabilizing the postprandial level of gut hormones such as glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptides, which function as incretins to help upregulate insulin secretion and β-cell mass. In this review, we summarized DPP-IV inhibitors and their mechanism of inhibition, activities of those isolated from various natural sources, and their capacity to overcome oxidative stress in disease conditions.https://www.mdpi.com/1424-8247/14/6/586dipeptidyl peptidase-IVglucagon-like peptide-1hyperglycemiaincretinantioxidant |
| spellingShingle | Anand-Krishna Singh Dhananjay Yadav Neha Sharma Jun-O Jin Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes Pharmaceuticals dipeptidyl peptidase-IV glucagon-like peptide-1 hyperglycemia incretin antioxidant |
| title | Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes |
| title_full | Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes |
| title_fullStr | Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes |
| title_full_unstemmed | Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes |
| title_short | Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes |
| title_sort | dipeptidyl peptidase dpp iv inhibitors with antioxidant potential isolated from natural sources a novel approach for the management of diabetes |
| topic | dipeptidyl peptidase-IV glucagon-like peptide-1 hyperglycemia incretin antioxidant |
| url | https://www.mdpi.com/1424-8247/14/6/586 |
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