Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea
Abstract Background The number of human Q fever cases in South Korea has been rapidly increasing since 2015. We report the first isolation of Coxiella burnetii in Korea in two patients who initially presented with non-specific febrile illness and were finally diagnosed with acute Q fever in South Ko...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05130-3 |
| _version_ | 1828532847590244352 |
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| author | Seung Hun Lee Jae Hoon Lee Sungdo Park Hae Kyung Lee Seon Do Hwang Hye Won Jeong Jung Yeon Heo Yeong Seon Lee |
| author_facet | Seung Hun Lee Jae Hoon Lee Sungdo Park Hae Kyung Lee Seon Do Hwang Hye Won Jeong Jung Yeon Heo Yeong Seon Lee |
| author_sort | Seung Hun Lee |
| collection | DOAJ |
| description | Abstract Background The number of human Q fever cases in South Korea has been rapidly increasing since 2015. We report the first isolation of Coxiella burnetii in Korea in two patients who initially presented with non-specific febrile illness and were finally diagnosed with acute Q fever in South Korea. Case presentation Two adult patients with fever had serologic tests against C. burnetii initially negative, and polymerase chain reaction against 16S rRNA using whole blood was also negative. After bacterial amplification of C. burnetii in immune-depressed mice, we isolated C. burnetii from patients with acute Q fever. The isolates KZQ2 and KZQ3 were confirmed by polymerase chain reaction, nucleotide sequence analysis, and morphologic observation using a transmission electron microscope. Conclusions These results can help us understand the clinical and epidemiologic features of Q fever in South Korea. |
| first_indexed | 2024-12-11T22:59:12Z |
| format | Article |
| id | doaj.art-fa18ce344e544552a0145524d81eb919 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-11T22:59:12Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-fa18ce344e544552a0145524d81eb9192022-12-22T00:47:07ZengBMCBMC Infectious Diseases1471-23342020-06-012011510.1186/s12879-020-05130-3Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South KoreaSeung Hun Lee0Jae Hoon Lee1Sungdo Park2Hae Kyung Lee3Seon Do Hwang4Hye Won Jeong5Jung Yeon Heo6Yeong Seon Lee7Division of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of HealthWonkwang University College of MedicineDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of HealthDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of HealthDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of HealthChungbuk National University College of MedicineDivision of Infectious Diseases, Ajou University School of MedicineDivision of Bacterial Disease Research, Center for Infectious Disease Research, Korea National Institute of HealthAbstract Background The number of human Q fever cases in South Korea has been rapidly increasing since 2015. We report the first isolation of Coxiella burnetii in Korea in two patients who initially presented with non-specific febrile illness and were finally diagnosed with acute Q fever in South Korea. Case presentation Two adult patients with fever had serologic tests against C. burnetii initially negative, and polymerase chain reaction against 16S rRNA using whole blood was also negative. After bacterial amplification of C. burnetii in immune-depressed mice, we isolated C. burnetii from patients with acute Q fever. The isolates KZQ2 and KZQ3 were confirmed by polymerase chain reaction, nucleotide sequence analysis, and morphologic observation using a transmission electron microscope. Conclusions These results can help us understand the clinical and epidemiologic features of Q fever in South Korea.http://link.springer.com/article/10.1186/s12879-020-05130-3Coxiella burnetiiQ feverCulture isolation, molecular sequencing, electron microscopy |
| spellingShingle | Seung Hun Lee Jae Hoon Lee Sungdo Park Hae Kyung Lee Seon Do Hwang Hye Won Jeong Jung Yeon Heo Yeong Seon Lee Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea BMC Infectious Diseases Coxiella burnetii Q fever Culture isolation, molecular sequencing, electron microscopy |
| title | Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea |
| title_full | Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea |
| title_fullStr | Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea |
| title_full_unstemmed | Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea |
| title_short | Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea |
| title_sort | isolation of coxiella burnetii in patients with nonspecific febrile illness in south korea |
| topic | Coxiella burnetii Q fever Culture isolation, molecular sequencing, electron microscopy |
| url | http://link.springer.com/article/10.1186/s12879-020-05130-3 |
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