Helminth Immunomodulation in Autoimmune Disease
Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensiv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00453/full |
| _version_ | 1811303347399950336 |
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| author | John J. Miles John J. Miles John J. Miles John J. Miles Taylor B. Smallwood Paul R. Giacomin Alex Loukas Jason P. Mulvenna Jason P. Mulvenna Jason P. Mulvenna Richard J. Clark |
| author_facet | John J. Miles John J. Miles John J. Miles John J. Miles Taylor B. Smallwood Paul R. Giacomin Alex Loukas Jason P. Mulvenna Jason P. Mulvenna Jason P. Mulvenna Richard J. Clark |
| author_sort | John J. Miles |
| collection | DOAJ |
| description | Helminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases. |
| first_indexed | 2024-04-13T07:46:22Z |
| format | Article |
| id | doaj.art-fa194f0b404b4905a77e45be34f1de1d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T07:46:22Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fa194f0b404b4905a77e45be34f1de1d2022-12-22T02:55:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-04-01810.3389/fimmu.2017.00453257359Helminth Immunomodulation in Autoimmune DiseaseJohn J. Miles0John J. Miles1John J. Miles2John J. Miles3Taylor B. Smallwood4Paul R. Giacomin5Alex Loukas6Jason P. Mulvenna7Jason P. Mulvenna8Jason P. Mulvenna9Richard J. Clark10Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UKSchool of Medicine, The University of Queensland, Brisbane, QLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, AustraliaCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, AustraliaCentre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, QLD, AustraliaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD, AustraliaHelminths have evolved to become experts at subverting immune surveillance. Through potent and persistent immune tempering, helminths can remain undetected in human tissues for decades. Redirecting the immunomodulating “talents” of helminths to treat inflammatory human diseases is receiving intensive interest. Here, we review therapies using live parasitic worms, worm secretions, and worm-derived synthetic molecules to treat autoimmune disease. We review helminth therapy in both mouse models and clinical trials and discuss what is known on mechanisms of action. We also highlight current progress in characterizing promising new immunomodulatory molecules found in excretory/secretory products of helminths and their potential use as immunotherapies for acute and chronic inflammatory diseases.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00453/fullhelminthic therapyautoimmunityimmunomodulationexcretory/secretory productsimmunotherapy |
| spellingShingle | John J. Miles John J. Miles John J. Miles John J. Miles Taylor B. Smallwood Paul R. Giacomin Alex Loukas Jason P. Mulvenna Jason P. Mulvenna Jason P. Mulvenna Richard J. Clark Helminth Immunomodulation in Autoimmune Disease Frontiers in Immunology helminthic therapy autoimmunity immunomodulation excretory/secretory products immunotherapy |
| title | Helminth Immunomodulation in Autoimmune Disease |
| title_full | Helminth Immunomodulation in Autoimmune Disease |
| title_fullStr | Helminth Immunomodulation in Autoimmune Disease |
| title_full_unstemmed | Helminth Immunomodulation in Autoimmune Disease |
| title_short | Helminth Immunomodulation in Autoimmune Disease |
| title_sort | helminth immunomodulation in autoimmune disease |
| topic | helminthic therapy autoimmunity immunomodulation excretory/secretory products immunotherapy |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00453/full |
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