Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer
Abstract Colorectal cancer (CRC) is the most common cancer of the digestive system with high mortality and morbidity rates. Gut microbiota is found in the intestines, especially the colorectum, and has structured crosstalk interactions with the host that affect several physiological processes. The g...
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202205563 |
| _version_ | 1797742713644253184 |
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| author | Ruize Qu Yi Zhang Yanpeng Ma Xin Zhou Lulu Sun Changtao Jiang Zhipeng Zhang Wei Fu |
| author_facet | Ruize Qu Yi Zhang Yanpeng Ma Xin Zhou Lulu Sun Changtao Jiang Zhipeng Zhang Wei Fu |
| author_sort | Ruize Qu |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is the most common cancer of the digestive system with high mortality and morbidity rates. Gut microbiota is found in the intestines, especially the colorectum, and has structured crosstalk interactions with the host that affect several physiological processes. The gut microbiota include CRC‐promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, and Bacteroides fragilis, and CRC‐protecting bacterial species, such as Clostridium butyricum, Streptococcus thermophilus, and Lacticaseibacillus paracasei, which along with other microorganisms, such as viruses and fungi, play critical roles in the development of CRC. Different bacterial features are identified in patients with early‐onset CRC, combined with different patterns between fecal and intratumoral microbiota. The gut microbiota may be beneficial in the diagnosis and treatment of CRC; some bacteria may serve as biomarkers while others as regulators of chemotherapy and immunotherapy. Furthermore, metabolites produced by the gut microbiota play essential roles in the crosstalk with CRC cells. Harmful metabolites include some primary bile acids and short‐chain fatty acids, whereas others, including ursodeoxycholic acid and butyrate, are beneficial and impede tumor development and progression. This review focuses on the gut microbiota and its metabolites, and their potential roles in the development, diagnosis, and treatment of CRC. |
| first_indexed | 2024-03-12T14:44:31Z |
| format | Article |
| id | doaj.art-fa1bbf496d6c49a285a52e361ad31fe8 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T14:44:31Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-fa1bbf496d6c49a285a52e361ad31fe82023-08-16T02:23:01ZengWileyAdvanced Science2198-38442023-08-011023n/an/a10.1002/advs.202205563Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal CancerRuize Qu0Yi Zhang1Yanpeng Ma2Xin Zhou3Lulu Sun4Changtao Jiang5Zhipeng Zhang6Wei Fu7Department of General Surgery Peking University Third Hospital Beijing 100191 P. R. ChinaDepartment of General Surgery Peking University Third Hospital Beijing 100191 P. R. ChinaDepartment of General Surgery Peking University Third Hospital Beijing 100191 P. R. ChinaDepartment of General Surgery Peking University Third Hospital Beijing 100191 P. R. ChinaState Key Laboratory of Women's Reproductive Health and Fertility Promotion Peking University Beijing 100191 P. R. ChinaCenter of Basic Medical Research Institute of Medical Innovation and Research Third Hospital Peking University Beijing 100191 P. R. ChinaDepartment of General Surgery Peking University Third Hospital Beijing 100191 P. R. ChinaDepartment of General Surgery Peking University Third Hospital Beijing 100191 P. R. ChinaAbstract Colorectal cancer (CRC) is the most common cancer of the digestive system with high mortality and morbidity rates. Gut microbiota is found in the intestines, especially the colorectum, and has structured crosstalk interactions with the host that affect several physiological processes. The gut microbiota include CRC‐promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, and Bacteroides fragilis, and CRC‐protecting bacterial species, such as Clostridium butyricum, Streptococcus thermophilus, and Lacticaseibacillus paracasei, which along with other microorganisms, such as viruses and fungi, play critical roles in the development of CRC. Different bacterial features are identified in patients with early‐onset CRC, combined with different patterns between fecal and intratumoral microbiota. The gut microbiota may be beneficial in the diagnosis and treatment of CRC; some bacteria may serve as biomarkers while others as regulators of chemotherapy and immunotherapy. Furthermore, metabolites produced by the gut microbiota play essential roles in the crosstalk with CRC cells. Harmful metabolites include some primary bile acids and short‐chain fatty acids, whereas others, including ursodeoxycholic acid and butyrate, are beneficial and impede tumor development and progression. This review focuses on the gut microbiota and its metabolites, and their potential roles in the development, diagnosis, and treatment of CRC.https://doi.org/10.1002/advs.202205563colorectal cancergut microbiotaintratumoral microbiotametaboliteprobiotic bacteriatumorigenesis |
| spellingShingle | Ruize Qu Yi Zhang Yanpeng Ma Xin Zhou Lulu Sun Changtao Jiang Zhipeng Zhang Wei Fu Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer Advanced Science colorectal cancer gut microbiota intratumoral microbiota metabolite probiotic bacteria tumorigenesis |
| title | Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer |
| title_full | Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer |
| title_fullStr | Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer |
| title_full_unstemmed | Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer |
| title_short | Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer |
| title_sort | role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer |
| topic | colorectal cancer gut microbiota intratumoral microbiota metabolite probiotic bacteria tumorigenesis |
| url | https://doi.org/10.1002/advs.202205563 |
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