Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran
Background: Records from the cancer registry system of Iran indicate that colorectal cancer is the third most common cancer in Iranian men and fourth most common among Iranian women. In this study we have investigated the environmental factors associated with colorectal cancer in Isfahan, Iran....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2018-10-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/720/393 |
| _version_ | 1818064393531817984 |
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| author | Miganoosh Simonian Sharifeh Khosravi Deniz Mortazavi Hadi Bagheri Rasoul Salehi Akbar Hassanzadeh Meysam Mosallaei |
| author_facet | Miganoosh Simonian Sharifeh Khosravi Deniz Mortazavi Hadi Bagheri Rasoul Salehi Akbar Hassanzadeh Meysam Mosallaei |
| author_sort | Miganoosh Simonian |
| collection | DOAJ |
| description | Background: Records from the cancer registry system of Iran indicate that
colorectal cancer is the third most common cancer in Iranian men and fourth most
common among Iranian women. In this study we have investigated the environmental
factors associated with colorectal cancer in Isfahan, Iran.
Methods: In this case-control study, we randomly selected 187 patients with
colorectal cancer who had positive results by colonoscopy and pathology (case group)
and 250 persons who had negative colonoscopy results (control group) from the
Colonoscopy Unit of Al Zahra Hospital and Colorectal Cancer Center of Seyed Al
Shohada Hospital from 2014 to mid-2015. This study aimed to find the risk factors for
sporadic colorectal cancer; therefore, we excluded patients with positive family history.
Participants completed a self-administered questionnaire that asked about sex, age, body
mass index, smoking status, job-related physical activity, and nonsteroidal antiinflammatory
drug consumption.
Results: This study enrolled 187 colorectal cancer patients (98 males and 89
females) and 250 individuals without colorectal cancer (107 males and 143 females).
Multiple analysis demonstrated a significant association of age (odds ratio: 1.04; 95%
confidence interval: 1.02, 1.06) and body mass index (odds ratio: 1.09; 95% confidence
interval: 1.03, 1.15) with colorectal cancer risk. Men had an almost two-fold risk
compared with women (odds ratio: 1.85; 95% confidence interval: 1.14, 2.99). Subjects
who did not use nonsteroidal anti-inflammatory drugs had an almost three-fold risk
compared with nonsteroidal anti-inflammatory drug consumers (odds ratio: 0.34; 95%
confidence interval: 0.19, 0.62). Analysis for job-related physical activity, also indicated
an association between the no/low active group with colorectal cancer (odds ratio no
activity: 36.09; 95% confidence interval: 10.94, 119 and odds ratio low activity: 2.96;
95% confidence interval: 1.43, 6.13).
Conclusion: Knowledge of the risk factors involved in colorectal cancer incidence
makes it possible to identify people at risk and begin risk reduction strategies as well
as screening programs. |
| first_indexed | 2024-12-10T14:35:17Z |
| format | Article |
| id | doaj.art-fa1d0a9b16154dc1b0ac1e86fd7c8828 |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-10T14:35:17Z |
| publishDate | 2018-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-fa1d0a9b16154dc1b0ac1e86fd7c88282022-12-22T01:44:51ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872018-10-0194318322Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, IranMiganoosh Simonian0Sharifeh Khosravi1Deniz Mortazavi2Hadi Bagheri3Rasoul Salehi4Akbar Hassanzadeh5Meysam Mosallaei6Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Records from the cancer registry system of Iran indicate that colorectal cancer is the third most common cancer in Iranian men and fourth most common among Iranian women. In this study we have investigated the environmental factors associated with colorectal cancer in Isfahan, Iran. Methods: In this case-control study, we randomly selected 187 patients with colorectal cancer who had positive results by colonoscopy and pathology (case group) and 250 persons who had negative colonoscopy results (control group) from the Colonoscopy Unit of Al Zahra Hospital and Colorectal Cancer Center of Seyed Al Shohada Hospital from 2014 to mid-2015. This study aimed to find the risk factors for sporadic colorectal cancer; therefore, we excluded patients with positive family history. Participants completed a self-administered questionnaire that asked about sex, age, body mass index, smoking status, job-related physical activity, and nonsteroidal antiinflammatory drug consumption. Results: This study enrolled 187 colorectal cancer patients (98 males and 89 females) and 250 individuals without colorectal cancer (107 males and 143 females). Multiple analysis demonstrated a significant association of age (odds ratio: 1.04; 95% confidence interval: 1.02, 1.06) and body mass index (odds ratio: 1.09; 95% confidence interval: 1.03, 1.15) with colorectal cancer risk. Men had an almost two-fold risk compared with women (odds ratio: 1.85; 95% confidence interval: 1.14, 2.99). Subjects who did not use nonsteroidal anti-inflammatory drugs had an almost three-fold risk compared with nonsteroidal anti-inflammatory drug consumers (odds ratio: 0.34; 95% confidence interval: 0.19, 0.62). Analysis for job-related physical activity, also indicated an association between the no/low active group with colorectal cancer (odds ratio no activity: 36.09; 95% confidence interval: 10.94, 119 and odds ratio low activity: 2.96; 95% confidence interval: 1.43, 6.13). Conclusion: Knowledge of the risk factors involved in colorectal cancer incidence makes it possible to identify people at risk and begin risk reduction strategies as well as screening programs.http://mejc.sums.ac.ir/index.php/mejc/article/view/720/393Colorectal cancerRisk factorsEnvironmental factors |
| spellingShingle | Miganoosh Simonian Sharifeh Khosravi Deniz Mortazavi Hadi Bagheri Rasoul Salehi Akbar Hassanzadeh Meysam Mosallaei Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran Middle East Journal of Cancer Colorectal cancer Risk factors Environmental factors |
| title | Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran |
| title_full | Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran |
| title_fullStr | Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran |
| title_full_unstemmed | Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran |
| title_short | Environmental Risk Factors Associated with Sporadic Colorectal Cancer in Isfahan, Iran |
| title_sort | environmental risk factors associated with sporadic colorectal cancer in isfahan iran |
| topic | Colorectal cancer Risk factors Environmental factors |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/720/393 |
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