Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints
Insomnia is characterized by sensory hypersensitivity and cognitive impairments. Recent work has identified the insula as a central brain region involved in both bottom-up gating of sensory information and top-down cognitive control. However, the specific relationships between insular subregion conn...
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| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnhum.2018.00035/full |
| _version_ | 1818446084979032064 |
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| author | Chun-Hong Liu Chun-Hong Liu Cun-Zhi Liu Xue-Qi Zhu Ji-Liang Fang Shun-Li Lu Li-Rong Tang Chuan-Yue Wang Qing-Quan Liu |
| author_facet | Chun-Hong Liu Chun-Hong Liu Cun-Zhi Liu Xue-Qi Zhu Ji-Liang Fang Shun-Li Lu Li-Rong Tang Chuan-Yue Wang Qing-Quan Liu |
| author_sort | Chun-Hong Liu |
| collection | DOAJ |
| description | Insomnia is characterized by sensory hypersensitivity and cognitive impairments. Recent work has identified the insula as a central brain region involved in both bottom-up gating of sensory information and top-down cognitive control. However, the specific relationships between insular subregion connectivity and emotional and cognitive functions remain unclear. In this study, resting-state functional magnetic resonance imaging data were obtained from 25 healthy participants with sleep complaints (HPS) and 25 age-, gender- and educational level-matched healthy participants without insomnia complaints (HP). We performed insular subregion (ventral anterior, dorsal anterior and posterior) functional connectivity (FC) analyses, and cognitive function was measured with several validated test procedures (e.g., the Wisconsin Card Sorting Test [WCST], Continuous Performance Test [CPT] and Trail making Test [TMT]). There were no significant differences between the two groups for WCST, CPT and TMT scores. The HPS group showed enhanced connectivity from the right posterior insula (R-PI) to the left postcentral gyrus (L-postCG) compared to HP group. WCST random errors (RE), sleep disturbance scores and HAMA scores correlated with this connectivity measurement in both HP and HPS groups. Our results provide direct evidence that the posterior insula (PI) synchronizes with sensorimotor areas to detect homeostatic changes and suggest that alteration of the latter is related to executive dysfunction in subjects with insomnia. |
| first_indexed | 2024-12-14T19:42:06Z |
| format | Article |
| id | doaj.art-fa1e76f6b6a44fd99cce1b2dd81bdfc6 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-14T19:42:06Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-fa1e76f6b6a44fd99cce1b2dd81bdfc62022-12-21T22:49:40ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-02-011210.3389/fnhum.2018.00035302727Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep ComplaintsChun-Hong Liu0Chun-Hong Liu1Cun-Zhi Liu2Xue-Qi Zhu3Ji-Liang Fang4Shun-Li Lu5Li-Rong Tang6Chuan-Yue Wang7Qing-Quan Liu8Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, ChinaDepartment of Radiology and Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaThe department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaDepartment of Psychosomatic Medicine/Administration of Medical Institution Conducting Clinical Trials for Human Used Drug, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaFunctional Brain Imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Radiology and Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology and Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology and Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing, ChinaBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, ChinaInsomnia is characterized by sensory hypersensitivity and cognitive impairments. Recent work has identified the insula as a central brain region involved in both bottom-up gating of sensory information and top-down cognitive control. However, the specific relationships between insular subregion connectivity and emotional and cognitive functions remain unclear. In this study, resting-state functional magnetic resonance imaging data were obtained from 25 healthy participants with sleep complaints (HPS) and 25 age-, gender- and educational level-matched healthy participants without insomnia complaints (HP). We performed insular subregion (ventral anterior, dorsal anterior and posterior) functional connectivity (FC) analyses, and cognitive function was measured with several validated test procedures (e.g., the Wisconsin Card Sorting Test [WCST], Continuous Performance Test [CPT] and Trail making Test [TMT]). There were no significant differences between the two groups for WCST, CPT and TMT scores. The HPS group showed enhanced connectivity from the right posterior insula (R-PI) to the left postcentral gyrus (L-postCG) compared to HP group. WCST random errors (RE), sleep disturbance scores and HAMA scores correlated with this connectivity measurement in both HP and HPS groups. Our results provide direct evidence that the posterior insula (PI) synchronizes with sensorimotor areas to detect homeostatic changes and suggest that alteration of the latter is related to executive dysfunction in subjects with insomnia.http://journal.frontiersin.org/article/10.3389/fnhum.2018.00035/fullresting-stateinsular subregionfunctional connectivityinsomniafMRI |
| spellingShingle | Chun-Hong Liu Chun-Hong Liu Cun-Zhi Liu Xue-Qi Zhu Ji-Liang Fang Shun-Li Lu Li-Rong Tang Chuan-Yue Wang Qing-Quan Liu Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints Frontiers in Human Neuroscience resting-state insular subregion functional connectivity insomnia fMRI |
| title | Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints |
| title_full | Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints |
| title_fullStr | Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints |
| title_full_unstemmed | Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints |
| title_short | Increased Posterior Insula-Sensorimotor Connectivity Is Associated with Cognitive Function in Healthy Participants with Sleep Complaints |
| title_sort | increased posterior insula sensorimotor connectivity is associated with cognitive function in healthy participants with sleep complaints |
| topic | resting-state insular subregion functional connectivity insomnia fMRI |
| url | http://journal.frontiersin.org/article/10.3389/fnhum.2018.00035/full |
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