SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice

SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice

We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, al...

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Bibliographic Details
Main Authors: Mariana Baz, Nikita Deshpande, Charlie Mackenzie-Kludas, Francesca Mordant, Danielle Anderson, Kanta Subbarao
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2022-11-01
Series:Emerging Infectious Diseases
Subjects:
COVID-19
coronavirus disease
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
viruses
respiratory infections
Online Access:https://wwwnc.cdc.gov/eid/article/28/11/22-0718_article
Description
Summary:We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.
ISSN:1080-6040
1080-6059

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