SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, al...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Centers for Disease Control and Prevention
2022-11-01
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Series: | Emerging Infectious Diseases |
Subjects: | |
Online Access: | https://wwwnc.cdc.gov/eid/article/28/11/22-0718_article |
Summary: | We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.
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ISSN: | 1080-6040 1080-6059 |