SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice
We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, al...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2022-11-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/11/22-0718_article |
| _version_ | 1811234419792412672 |
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| author | Mariana Baz Nikita Deshpande Charlie Mackenzie-Kludas Francesca Mordant Danielle Anderson Kanta Subbarao |
| author_facet | Mariana Baz Nikita Deshpande Charlie Mackenzie-Kludas Francesca Mordant Danielle Anderson Kanta Subbarao |
| author_sort | Mariana Baz |
| collection | DOAJ |
| description |
We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.
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| first_indexed | 2024-04-12T11:35:56Z |
| format | Article |
| id | doaj.art-fa1e7f5914a84bffb6b090f925d9d72a |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T11:35:56Z |
| publishDate | 2022-11-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-fa1e7f5914a84bffb6b090f925d9d72a2022-12-22T03:34:51ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-11-0128112352235510.3201/eid2811.220718SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in MiceMariana BazNikita DeshpandeCharlie Mackenzie-KludasFrancesca MordantDanielle AndersonKanta Subbarao We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection. https://wwwnc.cdc.gov/eid/article/28/11/22-0718_articleCOVID-19coronavirus diseaseSARS-CoV-2severe acute respiratory syndrome coronavirus 2virusesrespiratory infections |
| spellingShingle | Mariana Baz Nikita Deshpande Charlie Mackenzie-Kludas Francesca Mordant Danielle Anderson Kanta Subbarao SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice Emerging Infectious Diseases COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
| title | SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice |
| title_full | SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice |
| title_fullStr | SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice |
| title_full_unstemmed | SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice |
| title_short | SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice |
| title_sort | sars cov 2 omicron ba 1 challenge after ancestral or delta infection in mice |
| topic | COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
| url | https://wwwnc.cdc.gov/eid/article/28/11/22-0718_article |
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