Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study
Purpose: This study was conducted to examine microbiological profile with their antibiotic sensitivity in cases of bacterial keratitis in north and central India to ensure appropriate use of antibiotics. Methods: The microbiology laboratory records of 228 patients with culture-proven bacterial kerat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=12;spage=4263;epage=4269;aulast=Khurana |
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| author | Ashi Khurana Samrat Chatterjee Arpan Gandhi Prashant Borde Sanjay Chanda Sharad Nivrutti Gomase Manvi Aggarwal Gautam Singh Parmar Atanu Majumdar Priyanka Podder |
| author_facet | Ashi Khurana Samrat Chatterjee Arpan Gandhi Prashant Borde Sanjay Chanda Sharad Nivrutti Gomase Manvi Aggarwal Gautam Singh Parmar Atanu Majumdar Priyanka Podder |
| author_sort | Ashi Khurana |
| collection | DOAJ |
| description | Purpose: This study was conducted to examine microbiological profile with their antibiotic sensitivity in cases of bacterial keratitis in north and central India to ensure appropriate use of antibiotics. Methods: The microbiology laboratory records of 228 patients with culture-proven bacterial keratitis from 1st January to 31st December 2019 were analyzed. Cultured bacterial isolates were subjected to antimicrobial susceptibility testing to antibiotics commonly used in the treatment of corneal ulcer. Chi-squared or Fisher's exact test were applied to check the significance of difference between the susceptibility levels of antibiotics. Results: The prevalence of Staphylococcus aureus and Pseudomonas aeruginosa–induced keratitis was higher in northern India, whereas that by Streptococcus pneumoniae was more prevalent in central India. In central India, 100% of S. pneumoniae isolates were found to be sensitive to ceftriaxone compared to 79% in northern India (P = 0.017). In comparison to 67% of isolates from north India, 15% of S. aureus isolates from central India were found to be sensitive to ofloxacin (P = 0.009). Similarly, 23% of isolates from central India were found sensitive to amikacin compared to 65% of isolates from north India (P = 0.012). P. aeruginosa isolates from central India were found to be sensitive to ceftazidime in 63% of cases compared to 21% of isolates from north India (P = 0.034). Conclusion: Prevalence of bacteria and their susceptibility to antibiotics are not uniform across geography. Vancomycin remained the most effective drug in all gram-positive coccal infections. S. aureus susceptibility to amikacin was significantly greater in north India. P. aeruginosa showed less susceptibility as compared to previous reports. |
| first_indexed | 2024-04-12T02:06:22Z |
| format | Article |
| id | doaj.art-fa1f7db97fa1495885f67c79a3116e1e |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-12T02:06:22Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-fa1f7db97fa1495885f67c79a3116e1e2022-12-22T03:52:31ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892022-01-0170124263426910.4103/ijo.IJO_1438_22Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric studyAshi KhuranaSamrat ChatterjeeArpan GandhiPrashant BordeSanjay ChandaSharad Nivrutti GomaseManvi AggarwalGautam Singh ParmarAtanu MajumdarPriyanka PodderPurpose: This study was conducted to examine microbiological profile with their antibiotic sensitivity in cases of bacterial keratitis in north and central India to ensure appropriate use of antibiotics. Methods: The microbiology laboratory records of 228 patients with culture-proven bacterial keratitis from 1st January to 31st December 2019 were analyzed. Cultured bacterial isolates were subjected to antimicrobial susceptibility testing to antibiotics commonly used in the treatment of corneal ulcer. Chi-squared or Fisher's exact test were applied to check the significance of difference between the susceptibility levels of antibiotics. Results: The prevalence of Staphylococcus aureus and Pseudomonas aeruginosa–induced keratitis was higher in northern India, whereas that by Streptococcus pneumoniae was more prevalent in central India. In central India, 100% of S. pneumoniae isolates were found to be sensitive to ceftriaxone compared to 79% in northern India (P = 0.017). In comparison to 67% of isolates from north India, 15% of S. aureus isolates from central India were found to be sensitive to ofloxacin (P = 0.009). Similarly, 23% of isolates from central India were found sensitive to amikacin compared to 65% of isolates from north India (P = 0.012). P. aeruginosa isolates from central India were found to be sensitive to ceftazidime in 63% of cases compared to 21% of isolates from north India (P = 0.034). Conclusion: Prevalence of bacteria and their susceptibility to antibiotics are not uniform across geography. Vancomycin remained the most effective drug in all gram-positive coccal infections. S. aureus susceptibility to amikacin was significantly greater in north India. P. aeruginosa showed less susceptibility as compared to previous reports.http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=12;spage=4263;epage=4269;aulast=Khuranaantibiotic sensitivitybacterial keratitiscentral indianorth india |
| spellingShingle | Ashi Khurana Samrat Chatterjee Arpan Gandhi Prashant Borde Sanjay Chanda Sharad Nivrutti Gomase Manvi Aggarwal Gautam Singh Parmar Atanu Majumdar Priyanka Podder Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study Indian Journal of Ophthalmology antibiotic sensitivity bacterial keratitis central india north india |
| title | Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study |
| title_full | Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study |
| title_fullStr | Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study |
| title_full_unstemmed | Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study |
| title_short | Antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in North and Central India: A multi centric study |
| title_sort | antibiotic susceptibility pattern of bacterial isolates from microbial keratitis in north and central india a multi centric study |
| topic | antibiotic sensitivity bacterial keratitis central india north india |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=12;spage=4263;epage=4269;aulast=Khurana |
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