The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study
Abstract Background/Aims Helicobacter pylori (HP) eradication is recommended after endoscopic treatment of early gastric cancer (EGC). Cases of spontaneous HP resolution after partial gastrectomy due to environmental changes have been reported; however, there is no evidence for the efficacy of HP er...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1903 |
| _version_ | 1797344722236211200 |
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| author | Senichiro Yanagawa Nobuaki Fujikuni Kazuaki Tanabe Masahiro Nakahara Toshio Noriyuki |
| author_facet | Senichiro Yanagawa Nobuaki Fujikuni Kazuaki Tanabe Masahiro Nakahara Toshio Noriyuki |
| author_sort | Senichiro Yanagawa |
| collection | DOAJ |
| description | Abstract Background/Aims Helicobacter pylori (HP) eradication is recommended after endoscopic treatment of early gastric cancer (EGC). Cases of spontaneous HP resolution after partial gastrectomy due to environmental changes have been reported; however, there is no evidence for the efficacy of HP eradication in suppressing carcinogenesis and also no reports on the natural history of HP after partial gastrectomy in gastric cancer (GC). To report the natural history of HP in patients with GC and HP infection after partial gastrectomy. Methods and Results We prospectively studied the rate of spontaneous disappearance of HP after partial gastrectomy in patients with GC. From April 2016 to May 2020, 80 patients underwent partial gastrectomy, including 9 cases of proximal gastrectomy (PG), and 71 cases of distal gastrectomy (DG). The presence of HP was confirmed in the stool antigen test 1 year after operation, HP infection persisted in 46 patients (57.5%) and disappeared in 34 patients (42.5%). In univariate analysis, only proton pump inhibitor (PPI) use was a significant contributing factor for the spontaneous resolution of HP infection, especially in the DG group. However, there was no difference in the rates of HP disappearance between Billroth‐I and Roux‐en‐Y reconstructions in the DG group. Conclusion The HP spontaneously disappeared in 42.5% of the GC patients within 1 year after partial gastrectomy. Further investigation in a larger cohort is needed to elucidate the underlying mechanisms. |
| first_indexed | 2024-03-08T11:06:51Z |
| format | Article |
| id | doaj.art-fa20fd7a735c417ba8165114f7888ebf |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-03-08T11:06:51Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-fa20fd7a735c417ba8165114f7888ebf2024-01-26T14:41:21ZengWileyCancer Reports2573-83482023-12-01612n/an/a10.1002/cnr2.1903The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective studySenichiro Yanagawa0Nobuaki Fujikuni1Kazuaki Tanabe2Masahiro Nakahara3Toshio Noriyuki4Department of Surgery Onomichi General Hospital Hiroshima JapanDepartment of Surgery Onomichi General Hospital Hiroshima JapanDepartment of Perioperative and Critical Care Management, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Surgery Onomichi General Hospital Hiroshima JapanDepartment of Surgery Onomichi General Hospital Hiroshima JapanAbstract Background/Aims Helicobacter pylori (HP) eradication is recommended after endoscopic treatment of early gastric cancer (EGC). Cases of spontaneous HP resolution after partial gastrectomy due to environmental changes have been reported; however, there is no evidence for the efficacy of HP eradication in suppressing carcinogenesis and also no reports on the natural history of HP after partial gastrectomy in gastric cancer (GC). To report the natural history of HP in patients with GC and HP infection after partial gastrectomy. Methods and Results We prospectively studied the rate of spontaneous disappearance of HP after partial gastrectomy in patients with GC. From April 2016 to May 2020, 80 patients underwent partial gastrectomy, including 9 cases of proximal gastrectomy (PG), and 71 cases of distal gastrectomy (DG). The presence of HP was confirmed in the stool antigen test 1 year after operation, HP infection persisted in 46 patients (57.5%) and disappeared in 34 patients (42.5%). In univariate analysis, only proton pump inhibitor (PPI) use was a significant contributing factor for the spontaneous resolution of HP infection, especially in the DG group. However, there was no difference in the rates of HP disappearance between Billroth‐I and Roux‐en‐Y reconstructions in the DG group. Conclusion The HP spontaneously disappeared in 42.5% of the GC patients within 1 year after partial gastrectomy. Further investigation in a larger cohort is needed to elucidate the underlying mechanisms.https://doi.org/10.1002/cnr2.1903gastric cancerHelicobacter pyloripartial gastrectomyspontaneous disappearance |
| spellingShingle | Senichiro Yanagawa Nobuaki Fujikuni Kazuaki Tanabe Masahiro Nakahara Toshio Noriyuki The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study Cancer Reports gastric cancer Helicobacter pylori partial gastrectomy spontaneous disappearance |
| title | The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study |
| title_full | The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study |
| title_fullStr | The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study |
| title_full_unstemmed | The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study |
| title_short | The influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of Helicobacter pylori: A single‐center prospective study |
| title_sort | influence of partial gastrectomy for gastric cancer on the spontaneous disappearance of helicobacter pylori a single center prospective study |
| topic | gastric cancer Helicobacter pylori partial gastrectomy spontaneous disappearance |
| url | https://doi.org/10.1002/cnr2.1903 |
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