Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients
Aim:The aim of this study was to determine the relationship between left ventricular hypertrophy (LVH) and inflammatory markers in patients with type 2 Diabetes Mellitus (T2DM) with diabetic nephropathy at different stages.Methods:Our study was a cross-sectional study involving patients with various...
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| Format: | Article |
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Galenos Yayinevi
2020-03-01
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| Series: | Haseki Tıp Bülteni |
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http://www.hasekidergisi.com/archives/archive-detail/article-preview/nflammation-left-ventricular-mass-ndex-and-chronic/36496
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| author | Egemen Cebeci Nilay Şengül Samancı Sami Uzun Serhat Karadağ Meltem Gürsu Tuba Elif Şenel Özler Mustafa Velet Savaş Öztürk |
| author_facet | Egemen Cebeci Nilay Şengül Samancı Sami Uzun Serhat Karadağ Meltem Gürsu Tuba Elif Şenel Özler Mustafa Velet Savaş Öztürk |
| author_sort | Egemen Cebeci |
| collection | DOAJ |
| description | Aim:The aim of this study was to determine the relationship between left ventricular hypertrophy (LVH) and inflammatory markers in patients with type 2 Diabetes Mellitus (T2DM) with diabetic nephropathy at different stages.Methods:Our study was a cross-sectional study involving patients with various stage of T2DM. Patients with LVH were identified by 2D echocardiography. Plasma human tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-6, vaspin, vispatin and midkine were measured.Results:A total of 59 T2DM patients (56% women) with a mean age of 56.1±8.8 years were included in the study. The mean left ventricular mass index was 129±30. LVH was detected in 62.7% of the patients. Patients with an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2 had a higher incidence of LVH than patients with an eGFR ≥60 mL/min/1.73 m2 (p=0.03). The TNF-α levels in patients with LVH with low eGFR was found to be statistically significantly higher than in patients without LVH (p=0.047). The level of vaspin was statistically significantly higher in patients with LVH (p=0.01).Conclusion:LVH was found to be more frequent in patients with low eGFR, and from inflammatory markers, it was found to be associated only with TNF-α and vaspin. |
| first_indexed | 2024-04-10T12:58:47Z |
| format | Article |
| id | doaj.art-fa21dd5de0e74f85b5f2ab14253f0f82 |
| institution | Directory Open Access Journal |
| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T12:58:47Z |
| publishDate | 2020-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-fa21dd5de0e74f85b5f2ab14253f0f822023-02-15T16:13:22ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882020-03-0158212913410.4274/haseki.galenos.2020.566213049054Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic PatientsEgemen Cebeci0Nilay Şengül Samancı1Sami Uzun2Serhat Karadağ3Meltem Gürsu4Tuba Elif Şenel Özler5Mustafa Velet6Savaş Öztürk7 University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Nephrology, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Nephrology, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Nephrology, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Nephrology, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Nephrology, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkey University of Health Sciences Turkey, Haseki Training and Research Hospital, Clinic of Nephrology, İstanbul, Turkey Aim:The aim of this study was to determine the relationship between left ventricular hypertrophy (LVH) and inflammatory markers in patients with type 2 Diabetes Mellitus (T2DM) with diabetic nephropathy at different stages.Methods:Our study was a cross-sectional study involving patients with various stage of T2DM. Patients with LVH were identified by 2D echocardiography. Plasma human tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-6, vaspin, vispatin and midkine were measured.Results:A total of 59 T2DM patients (56% women) with a mean age of 56.1±8.8 years were included in the study. The mean left ventricular mass index was 129±30. LVH was detected in 62.7% of the patients. Patients with an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2 had a higher incidence of LVH than patients with an eGFR ≥60 mL/min/1.73 m2 (p=0.03). The TNF-α levels in patients with LVH with low eGFR was found to be statistically significantly higher than in patients without LVH (p=0.047). The level of vaspin was statistically significantly higher in patients with LVH (p=0.01).Conclusion:LVH was found to be more frequent in patients with low eGFR, and from inflammatory markers, it was found to be associated only with TNF-α and vaspin. http://www.hasekidergisi.com/archives/archive-detail/article-preview/nflammation-left-ventricular-mass-ndex-and-chronic/36496 left ventricular mass indexinflammatory markersdiabetic nephropathy |
| spellingShingle | Egemen Cebeci Nilay Şengül Samancı Sami Uzun Serhat Karadağ Meltem Gürsu Tuba Elif Şenel Özler Mustafa Velet Savaş Öztürk Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients Haseki Tıp Bülteni left ventricular mass index inflammatory markers diabetic nephropathy |
| title | Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients |
| title_full | Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients |
| title_fullStr | Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients |
| title_full_unstemmed | Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients |
| title_short | Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients |
| title_sort | inflammation left ventricular mass index and chronic renal failure in diabetic patients |
| topic | left ventricular mass index inflammatory markers diabetic nephropathy |
| url |
http://www.hasekidergisi.com/archives/archive-detail/article-preview/nflammation-left-ventricular-mass-ndex-and-chronic/36496
|
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