Outcomes of tuberculous meningitis in children: a case review study
Background Tuberculous meningitis is a severe extrapulmonary complication of tuberculosis, with high morbidity and mortality rates. Objective To assess the relationship between presenting clinical characteristics and outcomes of pediatric tuberculous meningitis. Methods We present a case review stud...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Indonesian Pediatric Society Publishing House
2011-10-01
|
| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/712 |
| _version_ | 1818610788228661248 |
|---|---|
| author | Yazid Dimyati Anna Tjandradjani Irawan Mangunatmadja Dwi Putro Widodo Hardiono D. Pusponegoro |
| author_facet | Yazid Dimyati Anna Tjandradjani Irawan Mangunatmadja Dwi Putro Widodo Hardiono D. Pusponegoro |
| author_sort | Yazid Dimyati |
| collection | DOAJ |
| description | Background Tuberculous meningitis is a severe extrapulmonary complication of tuberculosis, with high morbidity and mortality rates.
Objective To assess the relationship between presenting clinical characteristics and outcomes of pediatric tuberculous meningitis.
Methods We present a case review study of all children diagnosed with tuberculous meningitis in Cipto Mangunkusumo Hospital, Jakarta between January 1998 and December 2004. We compared demographic, clinical, and diagnostic characteristics to clinical outcomes.
Results We included 43 patients. Common characteristics on admission were young age (mean 3.2 years), stage II and III tuberculous meningitis (91%), and neurological symptoms existing for more than 1 week, including convulsions (52%), unconsciousness (23%), meningeal irritation (56%), and cranial nerve palsy (67%). A common feature of tuberculous meningitis on computed tomography scan of the brain was hydrocephalus in 19/24 cases. Clinical outcomes were neurological sequelae (88%) and death (12%). Factors associated with poor outcome in univariate analyses were young age, as well as stage II and III tuberculous meningitis.
Conclusions Tuberculous meningitis starts with nonspecific symptoms and is often only diagnosed when brain damage has already occurred. Outcome is directly associated with age and the stage of tuberculous meningitis. Earlier diagnosis may significantly improve outcomes. [Paediatr Indones. 2011;51:288-93]. |
| first_indexed | 2024-12-16T15:20:00Z |
| format | Article |
| id | doaj.art-fa24a056648e4ab0822a36d45ae6aeb8 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-16T15:20:00Z |
| publishDate | 2011-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-fa24a056648e4ab0822a36d45ae6aeb82022-12-21T22:26:41ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2011-10-015152889310.14238/pi51.5.2011.288-93576Outcomes of tuberculous meningitis in children: a case review studyYazid Dimyati0Anna Tjandradjani1Irawan Mangunatmadja2Dwi Putro Widodo3Hardiono D. Pusponegoro4Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North SumateraDepartment of Child Health, Harapan Kita Hospital, JakartaDepartment of Child Health, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Child Health, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Child Health, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, JakartaBackground Tuberculous meningitis is a severe extrapulmonary complication of tuberculosis, with high morbidity and mortality rates. Objective To assess the relationship between presenting clinical characteristics and outcomes of pediatric tuberculous meningitis. Methods We present a case review study of all children diagnosed with tuberculous meningitis in Cipto Mangunkusumo Hospital, Jakarta between January 1998 and December 2004. We compared demographic, clinical, and diagnostic characteristics to clinical outcomes. Results We included 43 patients. Common characteristics on admission were young age (mean 3.2 years), stage II and III tuberculous meningitis (91%), and neurological symptoms existing for more than 1 week, including convulsions (52%), unconsciousness (23%), meningeal irritation (56%), and cranial nerve palsy (67%). A common feature of tuberculous meningitis on computed tomography scan of the brain was hydrocephalus in 19/24 cases. Clinical outcomes were neurological sequelae (88%) and death (12%). Factors associated with poor outcome in univariate analyses were young age, as well as stage II and III tuberculous meningitis. Conclusions Tuberculous meningitis starts with nonspecific symptoms and is often only diagnosed when brain damage has already occurred. Outcome is directly associated with age and the stage of tuberculous meningitis. Earlier diagnosis may significantly improve outcomes. [Paediatr Indones. 2011;51:288-93].https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/712tuberculous meningitisoutcomeschildren |
| spellingShingle | Yazid Dimyati Anna Tjandradjani Irawan Mangunatmadja Dwi Putro Widodo Hardiono D. Pusponegoro Outcomes of tuberculous meningitis in children: a case review study Paediatrica Indonesiana tuberculous meningitis outcomes children |
| title | Outcomes of tuberculous meningitis in children: a case review study |
| title_full | Outcomes of tuberculous meningitis in children: a case review study |
| title_fullStr | Outcomes of tuberculous meningitis in children: a case review study |
| title_full_unstemmed | Outcomes of tuberculous meningitis in children: a case review study |
| title_short | Outcomes of tuberculous meningitis in children: a case review study |
| title_sort | outcomes of tuberculous meningitis in children a case review study |
| topic | tuberculous meningitis outcomes children |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/712 |
| work_keys_str_mv | AT yaziddimyati outcomesoftuberculousmeningitisinchildrenacasereviewstudy AT annatjandradjani outcomesoftuberculousmeningitisinchildrenacasereviewstudy AT irawanmangunatmadja outcomesoftuberculousmeningitisinchildrenacasereviewstudy AT dwiputrowidodo outcomesoftuberculousmeningitisinchildrenacasereviewstudy AT hardionodpusponegoro outcomesoftuberculousmeningitisinchildrenacasereviewstudy |