Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action

Copper is an endogenous metal ion that has been studied to prepare a new antitumoral agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS production, in the promotion of tumor progression, metastasis, and angiogenesis, and has been found at high levels in serum a...

Full description

Bibliographic Details
Main Authors:	Sebastiano Masuri, Petr Vaňhara, Maria Grazia Cabiddu, Lukáš Moráň, Josef Havel, Enzo Cadoni, Tiziana Pivetta
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Series:	Molecules
Subjects:	cancer coordination compounds copper 1,10-phenanthroline anticancer chemotherapy chemoresistance
Online Access:	https://www.mdpi.com/1420-3049/27/1/49

Similar Items

Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline
by: Kaloyanov Nikolay, et al.
Published: (2012-08-01)

Development of Copper Complexes with Diimines and Dipicolinate as Anticancer Cytotoxic Agents
by: Natalia Alvarez, et al.
Published: (2023-04-01)

Optimization of Castor Oil-Based Ion Selective Electrode (ISE) with Active Agent 1,10-Phenanthroline for Aqueous Pb<sup>2+</sup> Analysis
by: Khairun Nisah, et al.
Published: (2022-10-01)

Synthesis and Characterization of Some Mixed-Ligand Complexes Containing Azo Dye and 1,10-phenanthroline with CoII, ZnII, CdII and HgII Ions
by: Hasan A. Hasan, et al.
Published: (2017-03-01)

Design, Synthesis, Molecular Modelling and Anticancer Activities of New Fused Phenanthrolines
by: Cristina Maria Al Matarneh, et al.
Published: (2020-01-01)

The rapid synthesis of 1,10-phenanthroline-5,6-diimine (Phendiimine) and its fascinating photo-stimulated behavior
by: Ghasem Marandi, et al.
Published: (2024-04-01)

Decoding the anti-Leishmania braziliensis activity of 1,10-phenanthroline-5,6-dione and its silver- and copper-based complexes: In vitro and in vivo approaches
by: André L.S. Santos, et al.
Published: (2022-12-01)

Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs
by: M. Mustafa Cetin, et al.
Published: (2022-10-01)

Spectrophotometric quantification of dolutegravir based on redox reaction with Fe3+/1,10-phenanthroline
by: Swathi Naraparaju, et al.
Published: (2020-11-01)

1, 10-phenanthroline derivative as colorimetric and ratiometric fluorescence probe for Zn2+ and Cd2+
by: Guo Tian, et al.
Published: (2023-01-01)

Complexes of Some Transition Metal with 2-Benzoyl thiobenzimidazole and 1,10-Phenanthroline and Studying their Antibacterial Activity
by: Baghdad Science Journal
Published: (2016-06-01)

Synthesis and crystal structure of dichlorido(1,10-phenanthroline-κ2N,N′)gold(III) hexafluoridophosphate
by: Raphael Enoque Ferraz de Paiva, et al.
Published: (2017-07-01)

The Anti-<i>Leishmania amazonensis</i> and Anti-<i>Leishmania chagasi</i> Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds
by: Simone S. C. Oliveira, et al.
Published: (2023-01-01)

Heteroleptic [Cu(P^P)(N^N)][PF<sub>6</sub>] Compounds with Isomeric Dibromo-1,10-Phenanthroline Ligands
by: Isaak Nohara, et al.
Published: (2020-01-01)

Tris(1,10-phenanthroline-κ2N,N′)nickel(II) bis(hexafluoridophosphate)
by: Hicham El Hamdani, et al.
Published: (2018-05-01)

Synthesis and crystal structure of one new Pb(II) complex constructed by 1,10-phenanthroline and two carboxylate ligands
by: Zhang Lu-Lin, et al.
Published: (2021-06-01)

Synthesis and Spectral Analysis of Mn (II), Cu (II) ,Ni (II) and Cd (II) Complexes with Mixed Ligands containing 1,10-phenanthroline and Schiff base derived of 4-aminoantipyrine
by: Baghdad Science Journal
Published: (2014-12-01)

Synthesis and structural characterization of a novel lead coordination polymer: [Pb(L)(1,3-bdc)]·2H2O
by: Li Ziru, et al.
Published: (2022-09-01)

Ruthenium(II) Complexes with (3-Polyamino)phenanthrolines: Synthesis and Application in Sensing of Cu(II) Ions
by: Anton S. Abel, et al.
Published: (2022-02-01)

DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline
by: Nina Kasyanenko, et al.
Published: (2024-02-01)

Synthesis and crystal structure of one new cadmium coordination polymer constructed by phenanthroline derivate and 1,4-naphthalenedicarboxylic acid
by: Xu Na, et al.
Published: (2022-06-01)

Synthesis and Crystal Structure of Bis(Citrato)Germanate and Stannate with Tris(Phenanthroline)Nickel(II) Cation
by: Elena Martsinko, et al.
Published: (2018-12-01)

Dichlorido(4,7-dimethoxy-1,10-phenanthroline-κ2N,N′)zinc(II)
by: Nalani P. Rose, et al.
Published: (2024-01-01)

Sensitive spectrophotometric method for determination of catecholamines in pure and pharmaceutical formulations
by: Thabit Al-Ghabshaa, et al.
Published: (2007-04-01)

Development of a Simple Fe(II) Ion Colorimetric Sensor from the Immobilization of 1,10-Phenanthroline In Alginate/Pectin Film
by: Nindya Tri Muliawati, et al.
Published: (2020-12-01)

DNA Interactions and Biological Activity of 2,9-Disubstituted 1,10-Phenanthroline Thiosemicarbazone-Based Ligands and a 4-Phenylthiazole Derivative
by: Álvaro Nicolás, et al.
Published: (2024-01-01)

Dibromidobis(3-bromobenzyl-κC)(4,7-diphenyl-1,10-phenanthroline-κ2N,N′)tin(IV)
by: C. Bhaskar, et al.
Published: (2019-03-01)

Pyrrolidine-Derived Phenanthroline Diamides: An Influence of Fluorine Atoms on the Coordination of Lu(III) and Some Other f-Elements and Their Solvent Extraction
by: Nane A. Avagyan, et al.
Published: (2023-03-01)

Synthesis, Structure and Investigation of Germanium(IV) and Copper(II) Complexes with Malic Acid and 1,10ʹ-phenanthroline
by: Inna Seifullina, et al.
Published: (2017-12-01)

Synthesis and Characterization of Iridium(III) Complexes with Substituted Phenylimidazo(4,5-<i>f</i>)1,10-phenanthroline Ancillary Ligands and Their Application in LEC Devices
by: Bárbara Vásquez, et al.
Published: (2023-12-01)

Synthesis of Some Mixed ligands Complexes of (2-hydroxy benzaldine)-4-amino Antipyrine and 1,10-phenanthroline and Studying their antibacterial activity
by: Baghdad Science Journal
Published: (2017-03-01)

Poly(aquachlorobis(1,10–phenanthroline)copper(II)iodidemonohydrate)/GCE for simultaneous determination of caffeine and theophylline in human serum, tea, and tablet samples
by: Asefa Wagnew, et al.
Published: (2022-01-01)

Self-Assembled Molecular Complexes of 1,10-Phenanthroline and 2-Aminobenzimidazoles: Synthesis, Structure Investigations, and Cytotoxic Properties
by: Kameliya Anichina, et al.
Published: (2024-01-01)

Novel poly(diaquabis(1,10-phenanthroline)copper(II)chloride) modified glassy carbon electrode for square wave voltammetric determination of aspirin in tablet samples
by: Asnakech Mebrie, et al.
Published: (2022-01-01)

[Ni(1,10-phenanthroline)2(H2O)2](NO3)2: A Simple Coordination Complex with a Remarkably Complicated Structure that Simplifies on Heating
by: Timothy J. Prior, et al.
Published: (2011-09-01)

Mono and binuclear cobalt(II) mixed ligand complexes containing 1,10-phenanthroline and adenine using 1,3-diaminopropane as a spacer: synthesis, characterization, and antibacterial activity investigations
by: Atakilt Abebe, et al.
Published: (2020-05-01)

Indirect Way for the Assay of Captopril Drug in Dosage FormsUsing1,10-Phenanthroline as a Selective Spectrophotometric Agent for Fe(II) Via Homemade CFIA /Merging Zones Technique
by: Bushra B. Qassim, et al.
Published: (2018-05-01)

A new cadmium(ii) coordination polymer with 1,4-cyclohexanedicarboxylate acid and phenanthroline derivate: Synthesis and crystal structure
by: Su Beihao, et al.
Published: (2022-09-01)

Synthesis of a novel diaquabis(1,10-phenanthroline)copper(II)chloride complex and its voltammetric application for detection of amoxicillin in pharmaceutical and biological samples
by: Ameha Debalke, et al.
Published: (2022-10-01)

Electrochemical investigations into enzymatic polymerisation of 1,10-phenanthroline-5,6-dione as a redox mediator for lactate sensing
by: Grace Halpin, et al.
Published: (2021-11-01)