Sulforaphane Protects against Unilateral Ureteral Obstruction-Induced Renal Damage in Rats by Alleviating Mitochondrial and Lipid Metabolism Impairment

Sulforaphane Protects against Unilateral Ureteral Obstruction-Induced Renal Damage in Rats by Alleviating Mitochondrial and Lipid Metabolism Impairment

Unilateral ureteral obstruction (UUO) is an animal rodent model that allows the study of obstructive nephropathy in an accelerated manner. During UUO, tubular damage is induced, and alterations such as oxidative stress, inflammation, lipid metabolism, and mitochondrial impairment favor fibrosis deve...

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Bibliographic Details
Main Authors: Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sánchez-Lozada, Fernando Enrique García-Arroyo, Isabel Amador-Martínez, Marisol Orozco-Ibarra, Francisca Fernández-Valverde, José Pedraza-Chaverri
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Antioxidants
Subjects:
chronic kidney disease (CKD)
kidney fibrosis
mitochondrial biogenesis
mitochondrial dysfunction
lipid metabolism
sulforaphane (SFN)
Online Access:https://www.mdpi.com/2076-3921/11/10/1854

Internet

https://www.mdpi.com/2076-3921/11/10/1854

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