Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity

Controllable self-replicating RNA vaccine delivered intradermally elicits predominantly cellular immunity

Summary: Intradermal delivery of self-replicating RNA (srRNA) is a promising vaccine platform. We have developed an srRNA that functions optimally at around 33°C (skin temperature) and is inactivated at or above 37°C (core body temperature) as a safety switch. This temperature-controllable srRNA (c-...

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Bibliographic Details
Main Authors: Tomokazu Amano, Hong Yu, Misa Amano, Erica Leyder, Maria Badiola, Priyanka Ray, Jiyoung Kim, Akihiro C. Ko, Achouak Achour, Nan-ping Weng, Efrat Kochba, Yotam Levin, Minoru S.H. Ko
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Immunity
Molecular biology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223004121

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