3147 Electroencephalographic suppression from anesthesia and cognitive recovery
OBJECTIVES/SPECIFIC AIMS: (1) Assess if the total duration of EEG suppression during a protocolized exposure to general anesthesia predicts cognitive performance in multiple cognitive domains immediately following emergence from anesthesia. (2) Assess if the total duration of EEG suppression in the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2019-03-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866119002371/type/journal_article |
| _version_ | 1811156677460754432 |
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| author | Leonard Brian Hickman ShiNung Ching Mathias Basner Wei Wang Nan Lin Max Kelz George Mashour Michael S. Avidan Ben J. A. Palanca |
| author_facet | Leonard Brian Hickman ShiNung Ching Mathias Basner Wei Wang Nan Lin Max Kelz George Mashour Michael S. Avidan Ben J. A. Palanca |
| author_sort | Leonard Brian Hickman |
| collection | DOAJ |
| description | OBJECTIVES/SPECIFIC AIMS: (1) Assess if the total duration of EEG suppression during a protocolized exposure to general anesthesia predicts cognitive performance in multiple cognitive domains immediately following emergence from anesthesia. (2) Assess if the total duration of EEG suppression in the same individuals predicts the rate of cognitive recovery in a three-hour period following emergence from anesthesia. METHODS/STUDY POPULATION: This was a non-specified substudy of NCT01911195, a multicenter investigation taking place at the University of Michigan, University of Pennsylvania, and Washington University in St. Louis. 30 healthy volunteers aged 20-40 years were recruited to receive general anesthesia. Participants in the anesthesia arm were anesthetized for three hours at isoflurane levels compatible with surgery (1.3 MAC). Multichannel sensor nets were used for EEG acquisition during the anesthetic exposure. EEG suppression was detected through automated voltage-thresholded classification of 2-second signal epochs, with concordance assessed across sensors. Following return of responsiveness to verbal commands, participants completed up to three hours of serial cognitive tests assessing executive function, reaction time, cognitive throughput, and working memory. Non-linear mixed effects models will be used to estimate the initial cognitive deficit and the rate of cognitive recovery following anesthetic exposure; these measures of cognitive function will be assessed in relation to total duration of suppression during anesthesia. RESULTS/ANTICIPATED RESULTS: Participants displayed wide variability in the total amount of suppression during anesthesia, with a median of 31.2 minutes and range from 0 minutes to 115.2 minutes. Initial analyses suggest that greater duration of burst suppression had a weak relationship with participants’ initial cognitive deficits upon return of responsiveness from anesthesia. Model generation of rate of recovery following anesthetic exposure is pending, but we anticipate this will also have a weak relationship with burst suppression. DISCUSSION/SIGNIFICANCE OF IMPACT: In healthy adults receiving a standardized exposure to anesthesia without surgery, burst suppression appears to be a poor predictor of post-anesthesia cognitive task performance. This suggests that burst suppression may have limited utility as a predictive marker of post-operative cognitive functioning, particularly in young adults without significant illness. |
| first_indexed | 2024-04-10T04:55:24Z |
| format | Article |
| id | doaj.art-fa2909a9dc634577a0a413e109e64e02 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:55:24Z |
| publishDate | 2019-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-fa2909a9dc634577a0a413e109e64e022023-03-09T12:30:28ZengCambridge University PressJournal of Clinical and Translational Science2059-86612019-03-01310410410.1017/cts.2019.2373147 Electroencephalographic suppression from anesthesia and cognitive recoveryLeonard Brian Hickman0ShiNung Ching1Mathias Basner2Wei Wang3Nan Lin4Max Kelz5George Mashour6Michael S. Avidan7Ben J. A. Palanca8Washington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesWashington University in St. Louis, Institute Of Clinical and Translational SciencesOBJECTIVES/SPECIFIC AIMS: (1) Assess if the total duration of EEG suppression during a protocolized exposure to general anesthesia predicts cognitive performance in multiple cognitive domains immediately following emergence from anesthesia. (2) Assess if the total duration of EEG suppression in the same individuals predicts the rate of cognitive recovery in a three-hour period following emergence from anesthesia. METHODS/STUDY POPULATION: This was a non-specified substudy of NCT01911195, a multicenter investigation taking place at the University of Michigan, University of Pennsylvania, and Washington University in St. Louis. 30 healthy volunteers aged 20-40 years were recruited to receive general anesthesia. Participants in the anesthesia arm were anesthetized for three hours at isoflurane levels compatible with surgery (1.3 MAC). Multichannel sensor nets were used for EEG acquisition during the anesthetic exposure. EEG suppression was detected through automated voltage-thresholded classification of 2-second signal epochs, with concordance assessed across sensors. Following return of responsiveness to verbal commands, participants completed up to three hours of serial cognitive tests assessing executive function, reaction time, cognitive throughput, and working memory. Non-linear mixed effects models will be used to estimate the initial cognitive deficit and the rate of cognitive recovery following anesthetic exposure; these measures of cognitive function will be assessed in relation to total duration of suppression during anesthesia. RESULTS/ANTICIPATED RESULTS: Participants displayed wide variability in the total amount of suppression during anesthesia, with a median of 31.2 minutes and range from 0 minutes to 115.2 minutes. Initial analyses suggest that greater duration of burst suppression had a weak relationship with participants’ initial cognitive deficits upon return of responsiveness from anesthesia. Model generation of rate of recovery following anesthetic exposure is pending, but we anticipate this will also have a weak relationship with burst suppression. DISCUSSION/SIGNIFICANCE OF IMPACT: In healthy adults receiving a standardized exposure to anesthesia without surgery, burst suppression appears to be a poor predictor of post-anesthesia cognitive task performance. This suggests that burst suppression may have limited utility as a predictive marker of post-operative cognitive functioning, particularly in young adults without significant illness.https://www.cambridge.org/core/product/identifier/S2059866119002371/type/journal_article |
| spellingShingle | Leonard Brian Hickman ShiNung Ching Mathias Basner Wei Wang Nan Lin Max Kelz George Mashour Michael S. Avidan Ben J. A. Palanca 3147 Electroencephalographic suppression from anesthesia and cognitive recovery Journal of Clinical and Translational Science |
| title | 3147 Electroencephalographic suppression from anesthesia and cognitive recovery |
| title_full | 3147 Electroencephalographic suppression from anesthesia and cognitive recovery |
| title_fullStr | 3147 Electroencephalographic suppression from anesthesia and cognitive recovery |
| title_full_unstemmed | 3147 Electroencephalographic suppression from anesthesia and cognitive recovery |
| title_short | 3147 Electroencephalographic suppression from anesthesia and cognitive recovery |
| title_sort | 3147 electroencephalographic suppression from anesthesia and cognitive recovery |
| url | https://www.cambridge.org/core/product/identifier/S2059866119002371/type/journal_article |
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