Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice

Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice

Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontaneous pain. Oxidative mitochondrial damage in perip...

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Bibliographic Details
Main Authors: Mariko Ezaka, Eizo Marutani, Yusuke Miyazaki, Eiki Kanemaru, Martin K. Selig, Sophie L. Boerboom, Katrina F. Ostrom, Anat Stemmer-Rachamimov, Donald B. Bloch, Gary J. Brenner, Etsuo Ohshima, Fumito Ichinose
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antioxidants
Subjects:
paclitaxel-induced peripheral neuropathy
glutathione trisulfide
persulfide
persulfidation
Online Access:https://www.mdpi.com/2076-3921/11/11/2122

Internet

https://www.mdpi.com/2076-3921/11/11/2122

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