The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review
Epigenetic regulation has been thoroughly investigated in recent years and has emerged as an important aspect of chronic lymphocytic leukemia (CLL) biology. Characteristic aberrant features such as methylation patterns and global DNA hypomethylation were the early findings of the research during the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2024/1370364 |
| _version_ | 1797289076429160448 |
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| author | Sevastianos Chatzidavid Christina-Nefeli Kontandreopoulou Nefeli Giannakopoulou Panagiotis T. Diamantopoulos Christos Stafylidis Marie-Christine Kyrtsonis Maria Dimou Panayiotis Panayiotidis Nora-Athina Viniou |
| author_facet | Sevastianos Chatzidavid Christina-Nefeli Kontandreopoulou Nefeli Giannakopoulou Panagiotis T. Diamantopoulos Christos Stafylidis Marie-Christine Kyrtsonis Maria Dimou Panayiotis Panayiotidis Nora-Athina Viniou |
| author_sort | Sevastianos Chatzidavid |
| collection | DOAJ |
| description | Epigenetic regulation has been thoroughly investigated in recent years and has emerged as an important aspect of chronic lymphocytic leukemia (CLL) biology. Characteristic aberrant features such as methylation patterns and global DNA hypomethylation were the early findings of the research during the last decades. The investigation in this field led to the identification of a large number of genes where methylation features correlated with important clinical and laboratory parameters. Gene-specific analyses investigated methylation in the gene body enhancer regions as well as promoter regions. The findings included genes and proteins involved in key pathways that play central roles in the pathophysiology of the disease. Τhe application of these findings beyond the theoretical understanding can not only lead to the creation of prognostic and predictive models and scores but also to the design of novel therapeutic agents. The following is a review focusing on the present knowledge about single gene/gene promoter methylation or mRNA expression in CLL cases as well as records of older data that have been published in past papers. |
| first_indexed | 2024-03-07T18:58:58Z |
| format | Article |
| id | doaj.art-fa2a41aa5d3c45ea87c73f66a5b2392c |
| institution | Directory Open Access Journal |
| issn | 1687-9112 |
| language | English |
| last_indexed | 2024-03-07T18:58:58Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj.art-fa2a41aa5d3c45ea87c73f66a5b2392c2024-03-02T00:00:01ZengHindawi LimitedAdvances in Hematology1687-91122024-01-01202410.1155/2024/1370364The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic ReviewSevastianos Chatzidavid0Christina-Nefeli Kontandreopoulou1Nefeli Giannakopoulou2Panagiotis T. Diamantopoulos3Christos Stafylidis4Marie-Christine Kyrtsonis5Maria Dimou6Panayiotis Panayiotidis7Nora-Athina Viniou8Hematology UnitHematology UnitSecond Department of HematologyHematology UnitHematology UnitHematology Section of the First Department of Propaedeutic Internal MedicineHematology Section of the First Department of Propaedeutic Internal MedicineDepartment of Hematology and Bone Marrow Transplantation UnitHematology UnitEpigenetic regulation has been thoroughly investigated in recent years and has emerged as an important aspect of chronic lymphocytic leukemia (CLL) biology. Characteristic aberrant features such as methylation patterns and global DNA hypomethylation were the early findings of the research during the last decades. The investigation in this field led to the identification of a large number of genes where methylation features correlated with important clinical and laboratory parameters. Gene-specific analyses investigated methylation in the gene body enhancer regions as well as promoter regions. The findings included genes and proteins involved in key pathways that play central roles in the pathophysiology of the disease. Τhe application of these findings beyond the theoretical understanding can not only lead to the creation of prognostic and predictive models and scores but also to the design of novel therapeutic agents. The following is a review focusing on the present knowledge about single gene/gene promoter methylation or mRNA expression in CLL cases as well as records of older data that have been published in past papers.http://dx.doi.org/10.1155/2024/1370364 |
| spellingShingle | Sevastianos Chatzidavid Christina-Nefeli Kontandreopoulou Nefeli Giannakopoulou Panagiotis T. Diamantopoulos Christos Stafylidis Marie-Christine Kyrtsonis Maria Dimou Panayiotis Panayiotidis Nora-Athina Viniou The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review Advances in Hematology |
| title | The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review |
| title_full | The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review |
| title_fullStr | The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review |
| title_full_unstemmed | The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review |
| title_short | The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review |
| title_sort | role of methylation in chronic lymphocytic leukemia and its prognostic and therapeutic impacts in the disease a systematic review |
| url | http://dx.doi.org/10.1155/2024/1370364 |
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