Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. rich
Xylopia aethiopica is a plant used ethnomedicinally for the treatment of several infections in Nigeria. This study was carried out to isolate the active compound(s) in Xylopia aethiopica and evaluate their anti-measles virus activity. The Dichloromethane (DCM) fraction of Xylopia aethiopica was frac...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Scientific African |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468227622004100 |
| _version_ | 1827998542319321088 |
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| author | Bolaji B. Oluremi Paul M. Osamudiamen Johnson A. Adeniji Olapeju O. Aiyelaagbe |
| author_facet | Bolaji B. Oluremi Paul M. Osamudiamen Johnson A. Adeniji Olapeju O. Aiyelaagbe |
| author_sort | Bolaji B. Oluremi |
| collection | DOAJ |
| description | Xylopia aethiopica is a plant used ethnomedicinally for the treatment of several infections in Nigeria. This study was carried out to isolate the active compound(s) in Xylopia aethiopica and evaluate their anti-measles virus activity. The Dichloromethane (DCM) fraction of Xylopia aethiopica was fractionated using chromatographic techniques, which led to the isolation of a compound characterized using spectroscopic techniques, FT-IR, 1D and 2D NMR in addition to in vitro anti-measles evaluation in adsorption and post-infection inhibition assays. The isolated compound characterized as 4-Hydroxy-3-methoxy benzaldehyde (Vanillin) was active on measles virus and has minimum nontoxic dose of 10 µg with cytotoxic and inhibitory activity of CC50 = 84.18 µg/mL, IC50 = 0.71 µg/mL and selectivity index (SI) = 118.56 (r2 = 0.979) and interfered with viral attachment and fusion. This is the first report of the isolation of Vanillin from Xylopia aethiopica leaf and its high antiviral activity shows it could be developed further into a promising antiviral lead compound. |
| first_indexed | 2024-04-10T05:44:53Z |
| format | Article |
| id | doaj.art-fa2a467a9f5f4ab8a183ad7a8be92696 |
| institution | Directory Open Access Journal |
| issn | 2468-2276 |
| language | English |
| last_indexed | 2024-04-10T05:44:53Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Scientific African |
| spelling | doaj.art-fa2a467a9f5f4ab8a183ad7a8be926962023-03-06T04:17:04ZengElsevierScientific African2468-22762023-03-0119e01506Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. richBolaji B. Oluremi0Paul M. Osamudiamen1Johnson A. Adeniji2Olapeju O. Aiyelaagbe3Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria; Corresponding author.Department of Chemical Sciences, Bells University of Technology, Ogun State, Nigeria; Corresponding author.Department of Virology, College of Medicine, University of Ibadan, Ibadan, NigeriaDepartment of Chemistry, University of Ibadan, Ibadan, NigeriaXylopia aethiopica is a plant used ethnomedicinally for the treatment of several infections in Nigeria. This study was carried out to isolate the active compound(s) in Xylopia aethiopica and evaluate their anti-measles virus activity. The Dichloromethane (DCM) fraction of Xylopia aethiopica was fractionated using chromatographic techniques, which led to the isolation of a compound characterized using spectroscopic techniques, FT-IR, 1D and 2D NMR in addition to in vitro anti-measles evaluation in adsorption and post-infection inhibition assays. The isolated compound characterized as 4-Hydroxy-3-methoxy benzaldehyde (Vanillin) was active on measles virus and has minimum nontoxic dose of 10 µg with cytotoxic and inhibitory activity of CC50 = 84.18 µg/mL, IC50 = 0.71 µg/mL and selectivity index (SI) = 118.56 (r2 = 0.979) and interfered with viral attachment and fusion. This is the first report of the isolation of Vanillin from Xylopia aethiopica leaf and its high antiviral activity shows it could be developed further into a promising antiviral lead compound.http://www.sciencedirect.com/science/article/pii/S2468227622004100Xylopia aethiopicaMeasles virusAnti-measles virus activityVanillin4-hydroxy-3-methoxybenzaldehyde |
| spellingShingle | Bolaji B. Oluremi Paul M. Osamudiamen Johnson A. Adeniji Olapeju O. Aiyelaagbe Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. rich Scientific African Xylopia aethiopica Measles virus Anti-measles virus activity Vanillin 4-hydroxy-3-methoxybenzaldehyde |
| title | Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. rich |
| title_full | Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. rich |
| title_fullStr | Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. rich |
| title_full_unstemmed | Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. rich |
| title_short | Anti-measles virus activity of 4-hydroxy-3-methoxy benzaldehyde (Vanillin) isolated from Xylopia aethiopica (Dunal) A. rich |
| title_sort | anti measles virus activity of 4 hydroxy 3 methoxy benzaldehyde vanillin isolated from xylopia aethiopica dunal a rich |
| topic | Xylopia aethiopica Measles virus Anti-measles virus activity Vanillin 4-hydroxy-3-methoxybenzaldehyde |
| url | http://www.sciencedirect.com/science/article/pii/S2468227622004100 |
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