European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events
Few data have been published on the effects of impaired glucose metabolism induced by COVID-19 vaccines. We decided to perform a study to describe Individual Case Safety Reports (ICSRs) of impaired glucose metabolism events reported in the European database (Eudravigilance, EV). ICSRs were retrieved...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/6/677 |
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| author | Gabriella di Mauro Annamaria Mascolo Miriam Longo Maria Ida Maiorino Lorenzo Scappaticcio Giuseppe Bellastella Katherine Esposito Annalisa Capuano |
| author_facet | Gabriella di Mauro Annamaria Mascolo Miriam Longo Maria Ida Maiorino Lorenzo Scappaticcio Giuseppe Bellastella Katherine Esposito Annalisa Capuano |
| author_sort | Gabriella di Mauro |
| collection | DOAJ |
| description | Few data have been published on the effects of impaired glucose metabolism induced by COVID-19 vaccines. We decided to perform a study to describe Individual Case Safety Reports (ICSRs) of impaired glucose metabolism events reported in the European database (Eudravigilance, EV). ICSRs were retrieved from the online website of Eudravigilance. The reporting odds ratios (ROR) were computed to assess the reporting frequency for COVID-19 mRNA vaccines compared to COVID-19 viral vector-based vaccines. A total of 3917 ICSRs with a COVID-19 vaccine suspected were retrieved, with a total of 4275 impaired glucose metabolism events. Overall, the most reported events were related to “high glucose levels” (2012; 47.06%). The mRNA vaccines were associated with an increased reporting frequency of “type 1 diabetes mellitus” (ROR 1.86; 95% CI 1.33–2.60), “type 2 diabetes mellitus” (ROR 1.58; 95% CI 1.03–2.42), “high glucose levels” (ROR 1.16; 95% CI 1.06–1.27), “diabetes mellitus inadequate control” (ROR 1.63; 95% CI 1.25–2.11), and “hypoglycemia” (ROR 1.62; 95% CI 1.41–1.86) compared to viral vector-based vaccines. mRNA COVID-19 vaccines were associated with an increased reporting frequency of alterations of glucose homeostasis compared to viral-vector COVID-19 vaccines. Clinicians should be aware of these events to better manage glycemic perturbations. Larger nationwide studies are warranted to verify these findings. |
| first_indexed | 2024-03-09T22:47:58Z |
| format | Article |
| id | doaj.art-fa2a59b8dc2e462495a1f7c89e7ab076 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:47:58Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-fa2a59b8dc2e462495a1f7c89e7ab0762023-11-23T18:26:51ZengMDPI AGPharmaceuticals1424-82472022-05-0115667710.3390/ph15060677European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism EventsGabriella di Mauro0Annamaria Mascolo1Miriam Longo2Maria Ida Maiorino3Lorenzo Scappaticcio4Giuseppe Bellastella5Katherine Esposito6Annalisa Capuano7Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, ItalyCampania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyCampania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, 80138 Naples, ItalyFew data have been published on the effects of impaired glucose metabolism induced by COVID-19 vaccines. We decided to perform a study to describe Individual Case Safety Reports (ICSRs) of impaired glucose metabolism events reported in the European database (Eudravigilance, EV). ICSRs were retrieved from the online website of Eudravigilance. The reporting odds ratios (ROR) were computed to assess the reporting frequency for COVID-19 mRNA vaccines compared to COVID-19 viral vector-based vaccines. A total of 3917 ICSRs with a COVID-19 vaccine suspected were retrieved, with a total of 4275 impaired glucose metabolism events. Overall, the most reported events were related to “high glucose levels” (2012; 47.06%). The mRNA vaccines were associated with an increased reporting frequency of “type 1 diabetes mellitus” (ROR 1.86; 95% CI 1.33–2.60), “type 2 diabetes mellitus” (ROR 1.58; 95% CI 1.03–2.42), “high glucose levels” (ROR 1.16; 95% CI 1.06–1.27), “diabetes mellitus inadequate control” (ROR 1.63; 95% CI 1.25–2.11), and “hypoglycemia” (ROR 1.62; 95% CI 1.41–1.86) compared to viral vector-based vaccines. mRNA COVID-19 vaccines were associated with an increased reporting frequency of alterations of glucose homeostasis compared to viral-vector COVID-19 vaccines. Clinicians should be aware of these events to better manage glycemic perturbations. Larger nationwide studies are warranted to verify these findings.https://www.mdpi.com/1424-8247/15/6/677COVID-19 vaccinesdiabetes mellitusglucose metabolism eventssafetyEurope |
| spellingShingle | Gabriella di Mauro Annamaria Mascolo Miriam Longo Maria Ida Maiorino Lorenzo Scappaticcio Giuseppe Bellastella Katherine Esposito Annalisa Capuano European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events Pharmaceuticals COVID-19 vaccines diabetes mellitus glucose metabolism events safety Europe |
| title | European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events |
| title_full | European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events |
| title_fullStr | European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events |
| title_full_unstemmed | European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events |
| title_short | European Safety Analysis of mRNA and Viral Vector COVID-19 Vaccines on Glucose Metabolism Events |
| title_sort | european safety analysis of mrna and viral vector covid 19 vaccines on glucose metabolism events |
| topic | COVID-19 vaccines diabetes mellitus glucose metabolism events safety Europe |
| url | https://www.mdpi.com/1424-8247/15/6/677 |
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