Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues
Background: The surgical treatment of ameloblastoma of the jaws remains contentious due to the variable recurrence rate amongst its variants, the tumor's local invasive behavior, and the lack of consensus among surgeons concerning the extent of resection in the contiguous healthy tissues. Objec...
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| Format: | Article |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023034503 |
| _version_ | 1797815542925492224 |
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| author | Charles Ezechukwu Anyanechi Sameep S. Shetty |
| author_facet | Charles Ezechukwu Anyanechi Sameep S. Shetty |
| author_sort | Charles Ezechukwu Anyanechi |
| collection | DOAJ |
| description | Background: The surgical treatment of ameloblastoma of the jaws remains contentious due to the variable recurrence rate amongst its variants, the tumor's local invasive behavior, and the lack of consensus among surgeons concerning the extent of resection in the contiguous healthy tissues. Objective: To determine the recurrence rate of ameloblastoma and its association with the resection margins. Materials and methods: This is a retrospective cohort study of the medical records of patients who underwent surgical resection of the jaws as the primary modality of treatment for ameloblastoma. Clinical data over the 26 years were analyzed for age, gender, site of the lesion, size, radiographic appearance, histopathological sub-type, and the incidence of recurrence post-treatment. Descriptive and bivariate statistics were computed. Results: A retrospective audit of 234 cases was included in the study that was typical (solid/multicystic) ameloblastoma. The age of patients ranged from 20 to 66 years with a mean age of 33.4 ± 9.6 years, and a male-to-female ratio of 1.2: 1 (P = 0.52). The follicular and plexiform types accounted for the majority of histopathological variants (89.8%; P = 0.000). Overall, 6.8% of cases relapsed after the initial primary surgery. The rate of recurrence was high with a resection margin of 1.0 or 1.5 cm than 2.0 cm (P = 0.001). No case of recurrence was seen with a resection margin of 2.5 cm margin. Conclusion: A low recurrence rate of 6.8% was noted in our series of cases. A wide 2.5 cm resection margin is recommended in the adjacent healthy tissues. |
| first_indexed | 2024-03-13T08:24:23Z |
| format | Article |
| id | doaj.art-fa2be5a64a2c4f7eb8a771b07b5c3327 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:24:23Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-fa2be5a64a2c4f7eb8a771b07b5c33272023-05-31T04:47:01ZengElsevierHeliyon2405-84402023-05-0195e16243Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissuesCharles Ezechukwu Anyanechi0Sameep S. Shetty1Department of Oral and Maxillofacial Surgery, University of Calabar/University of Calabar Teaching Hospital, Calabar, Nigeria; Corresponding author. Department of Oral and Maxillofacial Surgery, University of Calabar Teaching Hospital, P. O. Box 3446, Eastern Highway, 540001, Calabar, Nigeria.Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangalore, 575001, India; Manipal Academy of Higher Education, a Constituent of MAHE, Manipal, IndiaBackground: The surgical treatment of ameloblastoma of the jaws remains contentious due to the variable recurrence rate amongst its variants, the tumor's local invasive behavior, and the lack of consensus among surgeons concerning the extent of resection in the contiguous healthy tissues. Objective: To determine the recurrence rate of ameloblastoma and its association with the resection margins. Materials and methods: This is a retrospective cohort study of the medical records of patients who underwent surgical resection of the jaws as the primary modality of treatment for ameloblastoma. Clinical data over the 26 years were analyzed for age, gender, site of the lesion, size, radiographic appearance, histopathological sub-type, and the incidence of recurrence post-treatment. Descriptive and bivariate statistics were computed. Results: A retrospective audit of 234 cases was included in the study that was typical (solid/multicystic) ameloblastoma. The age of patients ranged from 20 to 66 years with a mean age of 33.4 ± 9.6 years, and a male-to-female ratio of 1.2: 1 (P = 0.52). The follicular and plexiform types accounted for the majority of histopathological variants (89.8%; P = 0.000). Overall, 6.8% of cases relapsed after the initial primary surgery. The rate of recurrence was high with a resection margin of 1.0 or 1.5 cm than 2.0 cm (P = 0.001). No case of recurrence was seen with a resection margin of 2.5 cm margin. Conclusion: A low recurrence rate of 6.8% was noted in our series of cases. A wide 2.5 cm resection margin is recommended in the adjacent healthy tissues.http://www.sciencedirect.com/science/article/pii/S2405844023034503AmeloblastomaJawsResectionMarginRecurrence |
| spellingShingle | Charles Ezechukwu Anyanechi Sameep S. Shetty Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues Heliyon Ameloblastoma Jaws Resection Margin Recurrence |
| title | Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues |
| title_full | Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues |
| title_fullStr | Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues |
| title_full_unstemmed | Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues |
| title_short | Ameloblastoma of the jaws in adult: A retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues |
| title_sort | ameloblastoma of the jaws in adult a retrospective review of local recurrent lesions based on the resection margin in the adjacent apparent healthy tissues |
| topic | Ameloblastoma Jaws Resection Margin Recurrence |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023034503 |
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