Rheb-mTOR activation rescues Aβ-induced cognitive impairment and memory function by restoring miR-146 activity in glial cells

Rheb-mTOR activation rescues Aβ-induced cognitive impairment and memory function by restoring miR-146 activity in glial cells

Deposition of amyloid beta plaques in adult rat or human brain is associated with increased production of proinflammatory cytokines by associated glial cells that are responsible for degeneration of the diseased tissue. The expression of these cytokines is usually under check and is controlled at th...

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Bibliographic Details
Main Authors: Dipayan De, Ishita Mukherjee, Subhalakshmi Guha, Ramesh Kumar Paidi, Saikat Chakrabarti, Subhas C. Biswas, Suvendra N. Bhattacharyya
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
miRNAs
Astrocyte
Alzheimer’s disease
amyloid beta
cytokines
mTORC1 activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001025

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