Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016
INTRODUCTION: Multidrug-resistant organisms (MDROs) have been a major concern in King Saud Medical City (KSMC) recently. The number of cases with colistin resistance was growing rapidly in the first half of 2016, challenging the infection control practices and mandating a thorough outbreak investiga...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2019-11-01
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| Series: | The Pan African Medical Journal |
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https://www.panafrican-med-journal.com/content/article/34/162/pdf/162.pdf
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| author | Zayid Al Mayahi Shady Kamel Hala Amer Mark Beatty |
| author_facet | Zayid Al Mayahi Shady Kamel Hala Amer Mark Beatty |
| author_sort | Zayid Al Mayahi |
| collection | DOAJ |
| description | INTRODUCTION: Multidrug-resistant organisms (MDROs) have been a major concern in King Saud Medical City (KSMC) recently. The number of cases with colistin resistance was growing rapidly in the first half of 2016, challenging the infection control practices and mandating a thorough outbreak investigation. Objective: determining the extent of the outbreak, identifying risk factors and preventing further increase in the rates of MDROs. METHODS: reviewing the medical records of the 22 admitted cases with colistin resistance using an abstraction form composed of demographical data, comorbidities, details of current admissions, and procedures. Also, tracking patients' movements in the hospital, reviewing all cultures isolates, and reviewing the surveillance and infection control strategies. RESULTS: mean age was 49.71,17.824 (20-79 years), 90.9% were males, 63.6% cases admitted under medical unit. The average duration of stay in the ED was 1.23 day. Over 2/3 had hypertension and diabetes mellitus. Majority of patients staying between 20-40 days in the hospital and the average number of days until developing colistin resistance was 44.18. Resistance was solely related to two organisms that were Acinetobacter baumanni (59.1%) and Klebsiella pneumoniae (40. 9%). Ventilators and folly's catheters were equally (95.5%) used by 21 patients. The most common site of infection was respiratory (41.3%), of which most were sputum samples. Resistance of over 75% is recorded by Antibiotics like Tazocin, Ciprofloxacin, Imepenen and oxacillin. CONCLUSION: the uncontrolled use of antibiotics, prolonged stay in the Intensive Care Unit (ICU), frequent uses of different devices, are the potential risk factors of developing colistin resistance. |
| first_indexed | 2024-12-24T19:02:24Z |
| format | Article |
| id | doaj.art-fa2eb4833c38429e866eab6ff32bdf1c |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-24T19:02:24Z |
| publishDate | 2019-11-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-fa2eb4833c38429e866eab6ff32bdf1c2022-12-21T16:43:11ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882019-11-013416210.11604/pamj.2019.34.162.1999819998Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016Zayid Al Mayahi0Shady Kamel1Hala Amer2Mark Beatty3 Field Epidemiology Training Program, Ministry of Health, Riyadh, Saudi Arabia Field Epidemiology Training Program, Ministry of Health, Riyadh, Saudi Arabia Infection Control Administration, King Saud Medical City, Ministry of Health, Riyadh, KSA Field Epidemiology Training Program, Ministry of Health, Riyadh, Saudi Arabia INTRODUCTION: Multidrug-resistant organisms (MDROs) have been a major concern in King Saud Medical City (KSMC) recently. The number of cases with colistin resistance was growing rapidly in the first half of 2016, challenging the infection control practices and mandating a thorough outbreak investigation. Objective: determining the extent of the outbreak, identifying risk factors and preventing further increase in the rates of MDROs. METHODS: reviewing the medical records of the 22 admitted cases with colistin resistance using an abstraction form composed of demographical data, comorbidities, details of current admissions, and procedures. Also, tracking patients' movements in the hospital, reviewing all cultures isolates, and reviewing the surveillance and infection control strategies. RESULTS: mean age was 49.71,17.824 (20-79 years), 90.9% were males, 63.6% cases admitted under medical unit. The average duration of stay in the ED was 1.23 day. Over 2/3 had hypertension and diabetes mellitus. Majority of patients staying between 20-40 days in the hospital and the average number of days until developing colistin resistance was 44.18. Resistance was solely related to two organisms that were Acinetobacter baumanni (59.1%) and Klebsiella pneumoniae (40. 9%). Ventilators and folly's catheters were equally (95.5%) used by 21 patients. The most common site of infection was respiratory (41.3%), of which most were sputum samples. Resistance of over 75% is recorded by Antibiotics like Tazocin, Ciprofloxacin, Imepenen and oxacillin. CONCLUSION: the uncontrolled use of antibiotics, prolonged stay in the Intensive Care Unit (ICU), frequent uses of different devices, are the potential risk factors of developing colistin resistance. https://www.panafrican-med-journal.com/content/article/34/162/pdf/162.pdf colistin resistancemultidrug resistant organismsmdrosantibioticsksa |
| spellingShingle | Zayid Al Mayahi Shady Kamel Hala Amer Mark Beatty Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016 The Pan African Medical Journal colistin resistance multidrug resistant organisms mdros antibiotics ksa |
| title | Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016 |
| title_full | Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016 |
| title_fullStr | Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016 |
| title_full_unstemmed | Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016 |
| title_short | Outbreak of colistin-resistant organisms at a tertiary hospital in Riyadh, Saudi Arabia, 2016 |
| title_sort | outbreak of colistin resistant organisms at a tertiary hospital in riyadh saudi arabia 2016 |
| topic | colistin resistance multidrug resistant organisms mdros antibiotics ksa |
| url |
https://www.panafrican-med-journal.com/content/article/34/162/pdf/162.pdf
|
| work_keys_str_mv | AT zayidalmayahi outbreakofcolistinresistantorganismsatatertiaryhospitalinriyadhsaudiarabia2016 AT shadykamel outbreakofcolistinresistantorganismsatatertiaryhospitalinriyadhsaudiarabia2016 AT halaamer outbreakofcolistinresistantorganismsatatertiaryhospitalinriyadhsaudiarabia2016 AT markbeatty outbreakofcolistinresistantorganismsatatertiaryhospitalinriyadhsaudiarabia2016 |