Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent
Abstract An oesophageal fully covered self‐expanding metallic stent (SEMS) was placed in a 54‐year‐old Japanese man to relieve dysphagia owing to a stage cT1bN3M1c lung adenocarcinoma. High expression of programmed cell death‐ligand 1 was microscopically confirmed, and pembrolizumab was subsequently...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-05-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.554 |
| _version_ | 1828443047119028224 |
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| author | Ken‐ichi Tomiyama Norimasa Ito Kenichi Hayashi Yuki Kawamoto Hiroaki Shinoda Nobuyuki Katakami |
| author_facet | Ken‐ichi Tomiyama Norimasa Ito Kenichi Hayashi Yuki Kawamoto Hiroaki Shinoda Nobuyuki Katakami |
| author_sort | Ken‐ichi Tomiyama |
| collection | DOAJ |
| description | Abstract An oesophageal fully covered self‐expanding metallic stent (SEMS) was placed in a 54‐year‐old Japanese man to relieve dysphagia owing to a stage cT1bN3M1c lung adenocarcinoma. High expression of programmed cell death‐ligand 1 was microscopically confirmed, and pembrolizumab was subsequently administered. Several days later, the patient was hospitalized with septic shock, and severe mediastinitis and pneumonia caused by oesophageal SEMS‐induced oesophageal and bronchial perforations were observed. Thoracoscopic surgery was performed to drain the mediastinal abscess, and an additional oesophageal SEMS was placed to close the oesophageal perforation. The patient gradually recovered from the potentially fatal infection, and the SEMS was retrieved after confirming perforation closure. We re‐initiated pembrolizumab administration, and the patient responded well. The present report reveals the potential risk and effectiveness of SEMS, especially when administered with immune checkpoint inhibitors. |
| first_indexed | 2024-12-10T21:23:31Z |
| format | Article |
| id | doaj.art-fa2f6894c2d54daa900c79628e81b358 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-12-10T21:23:31Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-fa2f6894c2d54daa900c79628e81b3582022-12-22T01:33:04ZengWileyRespirology Case Reports2051-33802020-05-0184n/an/a10.1002/rcr2.554Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stentKen‐ichi Tomiyama0Norimasa Ito1Kenichi Hayashi2Yuki Kawamoto3Hiroaki Shinoda4Nobuyuki Katakami5Department of Thoracic Surgery Saiseikai Hyogoken Hospital Kobe JapanDepartment of Thoracic Surgery Saiseikai Hyogoken Hospital Kobe JapanDepartment of Gastrointestinal Medicine Saiseikai Hyogoken Hospital Kobe JapanDepartment of Gastrointestinal Medicine Saiseikai Hyogoken Hospital Kobe JapanDepartment of Gastrointestinal Medicine Saiseikai Hyogoken Hospital Kobe JapanDepartment of Respiratory Medicine Takarazuka Municipal Hospital Takarazuka JapanAbstract An oesophageal fully covered self‐expanding metallic stent (SEMS) was placed in a 54‐year‐old Japanese man to relieve dysphagia owing to a stage cT1bN3M1c lung adenocarcinoma. High expression of programmed cell death‐ligand 1 was microscopically confirmed, and pembrolizumab was subsequently administered. Several days later, the patient was hospitalized with septic shock, and severe mediastinitis and pneumonia caused by oesophageal SEMS‐induced oesophageal and bronchial perforations were observed. Thoracoscopic surgery was performed to drain the mediastinal abscess, and an additional oesophageal SEMS was placed to close the oesophageal perforation. The patient gradually recovered from the potentially fatal infection, and the SEMS was retrieved after confirming perforation closure. We re‐initiated pembrolizumab administration, and the patient responded well. The present report reveals the potential risk and effectiveness of SEMS, especially when administered with immune checkpoint inhibitors.https://doi.org/10.1002/rcr2.554Oesophagobronchial perforationpembrolizumabpneumoniaself‐expanding metallic stent |
| spellingShingle | Ken‐ichi Tomiyama Norimasa Ito Kenichi Hayashi Yuki Kawamoto Hiroaki Shinoda Nobuyuki Katakami Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent Respirology Case Reports Oesophagobronchial perforation pembrolizumab pneumonia self‐expanding metallic stent |
| title | Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent |
| title_full | Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent |
| title_fullStr | Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent |
| title_full_unstemmed | Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent |
| title_short | Oesophagobronchial perforations after placement of an oesophageal self‐expanding metallic stent |
| title_sort | oesophagobronchial perforations after placement of an oesophageal self expanding metallic stent |
| topic | Oesophagobronchial perforation pembrolizumab pneumonia self‐expanding metallic stent |
| url | https://doi.org/10.1002/rcr2.554 |
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