Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphim...

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Bibliographic Details
Main Authors: Philip Reigan, Brian G. Reid, Qiong Zhou, Amanda K. Ashley, Jac A. Nickoloff, Robert Hromas, Daniel V. LaBarbera, Courtney L. Amerin, Qun Li, Adedoyin D. Abraham, Byong Hoon Yoo, Jessica Ponder
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:Marine Drugs
Subjects:
neoamphimedine
topoisomerase II
Metnase
cancer therapeutics
Online Access:http://www.mdpi.com/1660-3397/9/11/2397/

Internet

http://www.mdpi.com/1660-3397/9/11/2397/

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