Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania.
BACKGROUND:Schistosomiasis is a neglected tropical disease that continues to cause morbidity and mortality in Sub Saharan Africa. Due to its endemicity, co-infection with malaria is common. The diseases cause anaemia and impaired nutritional status among children. We investigated the prevalence of i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0228770 |
| _version_ | 1819029907970195456 |
|---|---|
| author | Rajabu Hussein Mnkugwe Omary S Minzi Safari M Kinung'hi Appolinary A Kamuhabwa Eleni Aklillu |
| author_facet | Rajabu Hussein Mnkugwe Omary S Minzi Safari M Kinung'hi Appolinary A Kamuhabwa Eleni Aklillu |
| author_sort | Rajabu Hussein Mnkugwe |
| collection | DOAJ |
| description | BACKGROUND:Schistosomiasis is a neglected tropical disease that continues to cause morbidity and mortality in Sub Saharan Africa. Due to its endemicity, co-infection with malaria is common. The diseases cause anaemia and impaired nutritional status among children. We investigated the prevalence of intestinal schistosomiasis and its association with malaria, anaemia and nutritional status among school children. METHODS:This was a cross sectional survey among 830 children in Nyamikoma village along Lake Victoria in Tanzania. A pre-tested questionnaire was used to collect socio-demographic data, history of drug use, and clinical data. Two faecal samples were collected on two consecutive days and analyzed using thick smears Kato Katz method. Diagnosis of malaria was done by malaria rapid diagnostic test, and haemoglobin concentration was determined using HemoCue. Nutritional status was assessed by anthropometric measurements. RESULTS:The overall prevalence of intestinal schistosomiasis was 90.6% (95% CI = 88.6% - 92.6%). Intensity of infection was light 24.1% (200/830), moderate 38.4% (319/830) and heavy 28.1% (233/830). Pre-adolescents (≤12 years) were more infected with intestinal schistosomiasis (93.2%) than adolescents (>12 years) (84.7%) (p < 0.001). Prevalence of malaria was 1.7% (14/824), and that of intestinal schistosomiasis-malaria co-infection was 1.6% (13/824). The overall prevalence of anaemia was 24.6% (95%CI = 18.7% - 30.5%). Severe anaemia was found in 2.3% (19/824) of study participants. The prevalence of stunting and wasting were 29.0% and 11.3%, respectively. On both univariate and multivariate regression analysis, only lower age was significantly associated intestinal schistosomiasis infection, but not anemia, malaria, stunting or wasting. However among those infected, a negative binomial regression analysis indicated independent significant association of male sex, loose stool consistency, and stunting with high eggs count/gram of stool. CONCLUSIONS:Despite several rounds of annual mass praziquantel administration, intestinal schistosomiasis is highly prevalent among school children particularly in younger children living in the study area. Biannual targeted mass praziquantel treatments or alternative regimens may be considered in future in the study area to redress the situation. |
| first_indexed | 2024-12-21T06:21:43Z |
| format | Article |
| id | doaj.art-fa3285cfa6624f8d941d324fda8eea6d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T06:21:43Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fa3285cfa6624f8d941d324fda8eea6d2022-12-21T19:13:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01152e022877010.1371/journal.pone.0228770Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania.Rajabu Hussein MnkugweOmary S MinziSafari M Kinung'hiAppolinary A KamuhabwaEleni AklilluBACKGROUND:Schistosomiasis is a neglected tropical disease that continues to cause morbidity and mortality in Sub Saharan Africa. Due to its endemicity, co-infection with malaria is common. The diseases cause anaemia and impaired nutritional status among children. We investigated the prevalence of intestinal schistosomiasis and its association with malaria, anaemia and nutritional status among school children. METHODS:This was a cross sectional survey among 830 children in Nyamikoma village along Lake Victoria in Tanzania. A pre-tested questionnaire was used to collect socio-demographic data, history of drug use, and clinical data. Two faecal samples were collected on two consecutive days and analyzed using thick smears Kato Katz method. Diagnosis of malaria was done by malaria rapid diagnostic test, and haemoglobin concentration was determined using HemoCue. Nutritional status was assessed by anthropometric measurements. RESULTS:The overall prevalence of intestinal schistosomiasis was 90.6% (95% CI = 88.6% - 92.6%). Intensity of infection was light 24.1% (200/830), moderate 38.4% (319/830) and heavy 28.1% (233/830). Pre-adolescents (≤12 years) were more infected with intestinal schistosomiasis (93.2%) than adolescents (>12 years) (84.7%) (p < 0.001). Prevalence of malaria was 1.7% (14/824), and that of intestinal schistosomiasis-malaria co-infection was 1.6% (13/824). The overall prevalence of anaemia was 24.6% (95%CI = 18.7% - 30.5%). Severe anaemia was found in 2.3% (19/824) of study participants. The prevalence of stunting and wasting were 29.0% and 11.3%, respectively. On both univariate and multivariate regression analysis, only lower age was significantly associated intestinal schistosomiasis infection, but not anemia, malaria, stunting or wasting. However among those infected, a negative binomial regression analysis indicated independent significant association of male sex, loose stool consistency, and stunting with high eggs count/gram of stool. CONCLUSIONS:Despite several rounds of annual mass praziquantel administration, intestinal schistosomiasis is highly prevalent among school children particularly in younger children living in the study area. Biannual targeted mass praziquantel treatments or alternative regimens may be considered in future in the study area to redress the situation.https://doi.org/10.1371/journal.pone.0228770 |
| spellingShingle | Rajabu Hussein Mnkugwe Omary S Minzi Safari M Kinung'hi Appolinary A Kamuhabwa Eleni Aklillu Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania. PLoS ONE |
| title | Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania. |
| title_full | Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania. |
| title_fullStr | Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania. |
| title_full_unstemmed | Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania. |
| title_short | Prevalence and correlates of intestinal schistosomiasis infection among school-aged children in North-Western Tanzania. |
| title_sort | prevalence and correlates of intestinal schistosomiasis infection among school aged children in north western tanzania |
| url | https://doi.org/10.1371/journal.pone.0228770 |
| work_keys_str_mv | AT rajabuhusseinmnkugwe prevalenceandcorrelatesofintestinalschistosomiasisinfectionamongschoolagedchildreninnorthwesterntanzania AT omarysminzi prevalenceandcorrelatesofintestinalschistosomiasisinfectionamongschoolagedchildreninnorthwesterntanzania AT safarimkinunghi prevalenceandcorrelatesofintestinalschistosomiasisinfectionamongschoolagedchildreninnorthwesterntanzania AT appolinaryakamuhabwa prevalenceandcorrelatesofintestinalschistosomiasisinfectionamongschoolagedchildreninnorthwesterntanzania AT eleniaklillu prevalenceandcorrelatesofintestinalschistosomiasisinfectionamongschoolagedchildreninnorthwesterntanzania |