| Summary: | Recently, we have observed two significant pandemics caused by communicable (COVID-19) and non-communicable factors (obesity). Obesity is related to a specific genetic background and characterized by immunogenetic features, such as low-grade systemic inflammation. The specific genetic variants include the presence of polymorphism of the Peroxisome Proliferator-Activated Receptors gene (<i>PPAR-γ2</i>; Pro12Ala, rs1801282, and C1431T, rs3856806 polymorphisms), β-adrenergic receptor gene (<i>3β-AR</i>; Trp64Arg, rs4994), and Family With Sequence Similarity 13 Member A gene (<i>FAM13A</i>; rs1903003, rs7671167, rs2869967). This study aimed to analyze the genetic background, body fat distribution, and hypertension risk in obese metabolically healthy postmenopausal women (<i>n</i> = 229, including 105 lean and 124 obese subjects). Each patient underwent anthropometric and genetic evaluations. The study has shown that the highest value of BMI was associated with visceral fat distribution. The analysis of particular genotypes has revealed no differences between lean and obese women except for <i>FAM13A</i> rs1903003 (CC), which was more prevalent in lean patients. The co-existence of the <i>PPAR-γ2</i> C1431C variant with other <i>FAM13A</i> gene polymorphisms [rs1903003(TT) or rs7671167(TT), or rs2869967(CC)] was related to higher BMI values and visceral fat distribution (WHR > 0.85). The co-association of <i>FAM13A</i> rs1903003 (CC) and <i>3β-AR</i> Trp64Arg was associated with higher values of systolic (SBP) and diastolic blood pressure (DBP). We conclude that the co-existence of <i>FAM13A</i> variants with C1413C polymorphism of the <i>PPAR-γ2</i> gene is responsible for body fat amount and distribution.
|
|---|