Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages
<p>Abstract</p> <p>Background</p> <p>We sought to compare quantification of left ventricular volumes and ejection fraction by different gated myocardial perfusion SPECT (MPS) programs with each other and to magnetic resonance (MR) imaging.</p> <p>Methods<...
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| Format: | Article |
| Language: | English |
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BMC
2010-05-01
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| Series: | BMC Medical Imaging |
| Online Access: | http://www.biomedcentral.com/1471-2342/10/10 |
| _version_ | 1811252153158729728 |
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| author | Arheden Håkan Palmer John Hedeer Fredrik Ugander Martin |
| author_facet | Arheden Håkan Palmer John Hedeer Fredrik Ugander Martin |
| author_sort | Arheden Håkan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>We sought to compare quantification of left ventricular volumes and ejection fraction by different gated myocardial perfusion SPECT (MPS) programs with each other and to magnetic resonance (MR) imaging.</p> <p>Methods</p> <p>N = 100 patients with known or suspected coronary artery disease were examined at rest with <sup>99 m</sup>Tc-tetrofosmin gated MPS and cardiac MR imaging. Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were obtained by analysing gated MPS data with four different programs: Quantitative Gated SPECT (QGS), GE MyoMetrix, Emory Cardiac Toolbox (ECTb) and Exini heart.</p> <p>Results</p> <p>All programs showed a mean bias compared to MR imaging of approximately -30% for EDV (-22 to -34%, p < 0.001 for all), ESV (-12 to -37%, p < 0.001 for ECTb, p < 0.05 for Exini, p = ns for QGS and MyoMetrix) and SV (-21 to -41%, p < 0.001 for all). Mean bias ± 2 SD for EF (% of EF) was -9 ± 27% (p < 0.01), 6 ± 29% (p = ns), 15 ± 27% (p < 0.001) and 0 ± 28% (p = ns) for QGS, ECTb, MyoMetrix, and Exini, respectively.</p> <p>Conclusions</p> <p>Gated MPS, systematically underestimates left ventricular volumes by approximately 30% and shows a high variability, especially for ESV. For EF, accuracy was better, with a mean bias between -15 and 6% of EF. It may be of value to take this into consideration when determining absolute values of LV volumes and EF in a clinical setting.</p> |
| first_indexed | 2024-04-12T16:30:38Z |
| format | Article |
| id | doaj.art-fa355b1a15a6494faad82df9c3793423 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-04-12T16:30:38Z |
| publishDate | 2010-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-fa355b1a15a6494faad82df9c37934232022-12-22T03:25:10ZengBMCBMC Medical Imaging1471-23422010-05-011011010.1186/1471-2342-10-10Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packagesArheden HåkanPalmer JohnHedeer FredrikUgander Martin<p>Abstract</p> <p>Background</p> <p>We sought to compare quantification of left ventricular volumes and ejection fraction by different gated myocardial perfusion SPECT (MPS) programs with each other and to magnetic resonance (MR) imaging.</p> <p>Methods</p> <p>N = 100 patients with known or suspected coronary artery disease were examined at rest with <sup>99 m</sup>Tc-tetrofosmin gated MPS and cardiac MR imaging. Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were obtained by analysing gated MPS data with four different programs: Quantitative Gated SPECT (QGS), GE MyoMetrix, Emory Cardiac Toolbox (ECTb) and Exini heart.</p> <p>Results</p> <p>All programs showed a mean bias compared to MR imaging of approximately -30% for EDV (-22 to -34%, p < 0.001 for all), ESV (-12 to -37%, p < 0.001 for ECTb, p < 0.05 for Exini, p = ns for QGS and MyoMetrix) and SV (-21 to -41%, p < 0.001 for all). Mean bias ± 2 SD for EF (% of EF) was -9 ± 27% (p < 0.01), 6 ± 29% (p = ns), 15 ± 27% (p < 0.001) and 0 ± 28% (p = ns) for QGS, ECTb, MyoMetrix, and Exini, respectively.</p> <p>Conclusions</p> <p>Gated MPS, systematically underestimates left ventricular volumes by approximately 30% and shows a high variability, especially for ESV. For EF, accuracy was better, with a mean bias between -15 and 6% of EF. It may be of value to take this into consideration when determining absolute values of LV volumes and EF in a clinical setting.</p>http://www.biomedcentral.com/1471-2342/10/10 |
| spellingShingle | Arheden Håkan Palmer John Hedeer Fredrik Ugander Martin Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages BMC Medical Imaging |
| title | Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages |
| title_full | Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages |
| title_fullStr | Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages |
| title_full_unstemmed | Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages |
| title_short | Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging -- a comparison of four different commercial automated software packages |
| title_sort | gated myocardial perfusion spect underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging a comparison of four different commercial automated software packages |
| url | http://www.biomedcentral.com/1471-2342/10/10 |
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