Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were ob...
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| Format: | Article |
| Language: | English |
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MDPI AG
2000-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/5/7/927/ |
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| author | Emil Popovski Drazen Vikic-Topic Ljiljana Klisarova |
| author_facet | Emil Popovski Drazen Vikic-Topic Ljiljana Klisarova |
| author_sort | Emil Popovski |
| collection | DOAJ |
| description | Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as S(CH2NHBz)2 in a reaction of 1 with Na2S. Benzamidomethyl esters RCOOCH2NHBz were obtained (60-75%) in reactions of carboxylic acids with 1 in chloroform or dioxane. |
| first_indexed | 2024-12-11T09:25:44Z |
| format | Article |
| id | doaj.art-fa3617ef1cad43e0ade45eaf2ab6bd7f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T09:25:44Z |
| publishDate | 2000-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fa3617ef1cad43e0ade45eaf2ab6bd7f2022-12-22T01:13:10ZengMDPI AGMolecules1420-30492000-07-015792793610.3390/50700927Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic AcidsEmil PopovskiDrazen Vikic-TopicLjiljana KlisarovaThiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as S(CH2NHBz)2 in a reaction of 1 with Na2S. Benzamidomethyl esters RCOOCH2NHBz were obtained (60-75%) in reactions of carboxylic acids with 1 in chloroform or dioxane.http://www.mdpi.com/1420-3049/5/7/927/Benzamidomethylationthiolscarboxylic acidsamines |
| spellingShingle | Emil Popovski Drazen Vikic-Topic Ljiljana Klisarova Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids Molecules Benzamidomethylation thiols carboxylic acids amines |
| title | Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids |
| title_full | Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids |
| title_fullStr | Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids |
| title_full_unstemmed | Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids |
| title_short | Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids |
| title_sort | benzamidomethylation with benzamidomethyl triethylammonium chloride 2 a simple method for benzamidomethylation of thiols amines and carboxylic acids |
| topic | Benzamidomethylation thiols carboxylic acids amines |
| url | http://www.mdpi.com/1420-3049/5/7/927/ |
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