Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats
Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2007-06-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600012 |
| _version_ | 1818287383219535872 |
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| author | C.P. Veiga K.A. Miczek A.B. Lucion R.M.M. de Almeida |
| author_facet | C.P. Veiga K.A. Miczek A.B. Lucion R.M.M. de Almeida |
| author_sort | C.P. Veiga |
| collection | DOAJ |
| description | Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 µg/0.2 µL, N = 8, and 1.0 µg/0.2 µL, N = 8) or CP-93,129 (1.0 µg/0.2 µL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation. |
| first_indexed | 2024-12-13T01:39:37Z |
| format | Article |
| id | doaj.art-fa367cfd98ca46bab67b72f3d33f780e |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-13T01:39:37Z |
| publishDate | 2007-06-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-fa367cfd98ca46bab67b72f3d33f780e2022-12-22T00:03:48ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2007-06-01406825830Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in ratsC.P. VeigaK.A. MiczekA.B. LucionR.M.M. de AlmeidaSerotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 µg/0.2 µL, N = 8, and 1.0 µg/0.2 µL, N = 8) or CP-93,129 (1.0 µg/0.2 µL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600012Prefrontal cortex5-HT receptorsSerotoninMaternal behaviorAggression |
| spellingShingle | C.P. Veiga K.A. Miczek A.B. Lucion R.M.M. de Almeida Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats Brazilian Journal of Medical and Biological Research Prefrontal cortex 5-HT receptors Serotonin Maternal behavior Aggression |
| title | Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
| title_full | Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
| title_fullStr | Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
| title_full_unstemmed | Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
| title_short | Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
| title_sort | effect of 5 ht1b receptor agonists injected into the prefrontal cortex on maternal aggression in rats |
| topic | Prefrontal cortex 5-HT receptors Serotonin Maternal behavior Aggression |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600012 |
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