B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of rhesus macaques.

B cell clonal lineage alterations upon recombinant HIV-1 envelope immunization of rhesus macaques.

Broadly neutralizing HIV-1 antibodies (bNAbs) isolated from infected subjects display protective potential in animal models. Their elicitation by immunization is thus highly desirable. The HIV-1 envelope glycoprotein (Env) is the sole viral target of bnAbs, but is also targeted by binding, non-neutr...

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Bibliographic Details
Main Authors: Christina Yacoob, Miles Darnell Lange, Kristen Cohen, Kanan Lathia, Junli Feng, Jolene Glenn, Sara Carbonetti, Brian Oliver, Vladimir Vigdorovich, David Noah Sather, Leonidas Stamatatos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007120

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