Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials
BackgroundThere is conflicting data on the effect of vitamin K supplementation against vascular calcification in chronic kidney disease (CKD). We aimed to summarize current evidence from randomized controlled trials (RCTs) to determine whether vitamin K supplementation in CKD could attenuate vascula...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1001826/full |
| _version_ | 1797956415729434624 |
|---|---|
| author | Chanyu Geng Chanyu Geng Liming Huang Liming Huang Lei Pu Lei Pu Yunlin Feng Yunlin Feng |
| author_facet | Chanyu Geng Chanyu Geng Liming Huang Liming Huang Lei Pu Lei Pu Yunlin Feng Yunlin Feng |
| author_sort | Chanyu Geng |
| collection | DOAJ |
| description | BackgroundThere is conflicting data on the effect of vitamin K supplementation against vascular calcification in chronic kidney disease (CKD). We aimed to summarize current evidence from randomized controlled trials (RCTs) to determine whether vitamin K supplementation in CKD could attenuate vascular calcification.MethodsA systematic search was performed in MEDLINE, EMBASE, and Cochrane Central Library. RCTs assessing the effect of vitamin K supplementation on vascular calcification in CKD and reported measures relevant to vascular calcification were eligible for inclusion. Effect outcomes are changes of biochemical and imaging measures of vascular calcification, as well as vascular elasticity reflected by pulse wave velocity (PWV). Safety outcomes included any adverse event and death. The risk of bias was assessed according to Cochrane handbook guidelines. Mean differences or standardized mean differences (SMD) with 95% confidence intervals (CIs) of absolute and relative changes of each studied outcome between experimental and control groups were pooled using a random-effects model.ResultsIn all, ten RCTs with 733 patients were included. Pooled results indicated a decrease in serum biomarkers relevant to vascular calcification to a certain extent, mild improvement in vascular elasticity reflected by PWV, yet, no significant change in calcification scores derived from radiology examinations. Half of the included studies had low risk of bias.ConclusionTherefore, there is not yet solid evidence to support protective effects of vitamin K supplementation against vascular calcification in CKD. The results of ongoing RCTs are needed to further elucidate the value of vitamin K in this field.Systematic review registrationwww.crd.york.ac.uk/prospero, identifier CRD42022343857. |
| first_indexed | 2024-04-10T23:48:42Z |
| format | Article |
| id | doaj.art-fa382ff2589b438f9ebbc55b6b709351 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T23:48:42Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-fa382ff2589b438f9ebbc55b6b7093512023-01-10T22:04:38ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.10018261001826Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trialsChanyu Geng0Chanyu Geng1Liming Huang2Liming Huang3Lei Pu4Lei Pu5Yunlin Feng6Yunlin Feng7Department of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaInternal Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaInternal Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaInternal Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaInternal Medicine, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaBackgroundThere is conflicting data on the effect of vitamin K supplementation against vascular calcification in chronic kidney disease (CKD). We aimed to summarize current evidence from randomized controlled trials (RCTs) to determine whether vitamin K supplementation in CKD could attenuate vascular calcification.MethodsA systematic search was performed in MEDLINE, EMBASE, and Cochrane Central Library. RCTs assessing the effect of vitamin K supplementation on vascular calcification in CKD and reported measures relevant to vascular calcification were eligible for inclusion. Effect outcomes are changes of biochemical and imaging measures of vascular calcification, as well as vascular elasticity reflected by pulse wave velocity (PWV). Safety outcomes included any adverse event and death. The risk of bias was assessed according to Cochrane handbook guidelines. Mean differences or standardized mean differences (SMD) with 95% confidence intervals (CIs) of absolute and relative changes of each studied outcome between experimental and control groups were pooled using a random-effects model.ResultsIn all, ten RCTs with 733 patients were included. Pooled results indicated a decrease in serum biomarkers relevant to vascular calcification to a certain extent, mild improvement in vascular elasticity reflected by PWV, yet, no significant change in calcification scores derived from radiology examinations. Half of the included studies had low risk of bias.ConclusionTherefore, there is not yet solid evidence to support protective effects of vitamin K supplementation against vascular calcification in CKD. The results of ongoing RCTs are needed to further elucidate the value of vitamin K in this field.Systematic review registrationwww.crd.york.ac.uk/prospero, identifier CRD42022343857.https://www.frontiersin.org/articles/10.3389/fnut.2022.1001826/fullvitamin Kvascular calcificationchronic kidney diseasesystematic reviewmeta-analysis |
| spellingShingle | Chanyu Geng Chanyu Geng Liming Huang Liming Huang Lei Pu Lei Pu Yunlin Feng Yunlin Feng Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials Frontiers in Nutrition vitamin K vascular calcification chronic kidney disease systematic review meta-analysis |
| title | Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials |
| title_full | Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials |
| title_short | Effects of vitamin K supplementation on vascular calcification in chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials |
| title_sort | effects of vitamin k supplementation on vascular calcification in chronic kidney disease a systematic review and meta analysis of randomized controlled trials |
| topic | vitamin K vascular calcification chronic kidney disease systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1001826/full |
| work_keys_str_mv | AT chanyugeng effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT chanyugeng effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT liminghuang effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT liminghuang effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT leipu effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT leipu effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT yunlinfeng effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT yunlinfeng effectsofvitaminksupplementationonvascularcalcificationinchronickidneydiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |