Photoacoustic imaging a PDT response marker for monitoring vasculature changes
Photoacoustic imaging (PAI) is an evolving modality for studying and imaging tumor hypoxia. The experimental results from animals treated with ALA for Pre-PDT, Post-PDT, 4hr PDT, 24 hr PDT show a short-term increase in the BV followed by a strong decrease; however, no complete stasis. An alternate m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722006619 |
| _version_ | 1797952889373589504 |
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| author | M. Atif Lothar Lilge Atif Hanif Shafiq Ahmad S. Devanesan |
| author_facet | M. Atif Lothar Lilge Atif Hanif Shafiq Ahmad S. Devanesan |
| author_sort | M. Atif |
| collection | DOAJ |
| description | Photoacoustic imaging (PAI) is an evolving modality for studying and imaging tumor hypoxia. The experimental results from animals treated with ALA for Pre-PDT, Post-PDT, 4hr PDT, 24 hr PDT show a short-term increase in the BV followed by a strong decrease; however, no complete stasis. An alternate method is created by looking at the spatial and frequency domain histogram to observe the tumor vasculature. The images are represented in frequency domains by application of two-dimensional Fast Fourier Transform (FFT) on spatial domain images. The variations in acoustic impedance after Photodynamic Therapy (PDT) are studied. The photoacoustic signals implemented on tumor models indicated PDT influenced variations in the hemoglobin levels against different time periods and studied their outcome on the tumor necrosis. |
| first_indexed | 2024-04-10T22:53:12Z |
| format | Article |
| id | doaj.art-fa3aaa2446c3451b81b573f1b173fd67 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-10T22:53:12Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-fa3aaa2446c3451b81b573f1b173fd672023-01-15T04:21:18ZengElsevierJournal of King Saud University: Science1018-36472023-02-01352102480Photoacoustic imaging a PDT response marker for monitoring vasculature changesM. Atif0Lothar Lilge1Atif Hanif2Shafiq Ahmad3S. Devanesan4Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaPrincess Margaret Cancer Centre at University Health Research, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, CanadaBotany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaIndustrial Engineering Department, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia; Corresponding author.Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaPhotoacoustic imaging (PAI) is an evolving modality for studying and imaging tumor hypoxia. The experimental results from animals treated with ALA for Pre-PDT, Post-PDT, 4hr PDT, 24 hr PDT show a short-term increase in the BV followed by a strong decrease; however, no complete stasis. An alternate method is created by looking at the spatial and frequency domain histogram to observe the tumor vasculature. The images are represented in frequency domains by application of two-dimensional Fast Fourier Transform (FFT) on spatial domain images. The variations in acoustic impedance after Photodynamic Therapy (PDT) are studied. The photoacoustic signals implemented on tumor models indicated PDT influenced variations in the hemoglobin levels against different time periods and studied their outcome on the tumor necrosis.http://www.sciencedirect.com/science/article/pii/S1018364722006619Photoacoustic imagingTumor hypoxiaAcoustic impedance |
| spellingShingle | M. Atif Lothar Lilge Atif Hanif Shafiq Ahmad S. Devanesan Photoacoustic imaging a PDT response marker for monitoring vasculature changes Journal of King Saud University: Science Photoacoustic imaging Tumor hypoxia Acoustic impedance |
| title | Photoacoustic imaging a PDT response marker for monitoring vasculature changes |
| title_full | Photoacoustic imaging a PDT response marker for monitoring vasculature changes |
| title_fullStr | Photoacoustic imaging a PDT response marker for monitoring vasculature changes |
| title_full_unstemmed | Photoacoustic imaging a PDT response marker for monitoring vasculature changes |
| title_short | Photoacoustic imaging a PDT response marker for monitoring vasculature changes |
| title_sort | photoacoustic imaging a pdt response marker for monitoring vasculature changes |
| topic | Photoacoustic imaging Tumor hypoxia Acoustic impedance |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722006619 |
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