Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy
Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations of the h-current in several animal models. While prior reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we recently found an upregulation...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2009-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.01.005.2009/full |
| _version_ | 1828431843764994048 |
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| author | Jonas Dyhrfjeld-Johnsen Jonas Dyhrfjeld-Johnsen Robert J Morgan Ivan Soltesz |
| author_facet | Jonas Dyhrfjeld-Johnsen Jonas Dyhrfjeld-Johnsen Robert J Morgan Ivan Soltesz |
| author_sort | Jonas Dyhrfjeld-Johnsen |
| collection | DOAJ |
| description | Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations of the h-current in several animal models. While prior reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we recently found an upregulation of Ih in hyperexcitable CA1 pyramidal neuron dendrites following experimental febrile seizures. In addition, in several CA1 pyramidal neuron computational models of different complexity, h-current upregulation has been shown to lead to pro-excitable effects. This focused review examines the complex impact of altered h-current on neuronal resting membrane potential (RMP) and input resistance (Rin), as well as reported interactions with other ionic conductances. |
| first_indexed | 2024-12-10T18:09:32Z |
| format | Article |
| id | doaj.art-fa3af21649e34b4e919d0469d2b036f9 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T18:09:32Z |
| publishDate | 2009-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-fa3af21649e34b4e919d0469d2b036f92022-12-22T01:38:31ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2009-05-01310.3389/neuro.01.005.2009496Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsyJonas Dyhrfjeld-Johnsen0Jonas Dyhrfjeld-Johnsen1Robert J Morgan2Ivan Soltesz3Harvard Medical SchoolMassachusetts General HospitalUniversity of California - IrvineUniversity of California - IrvineStudies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations of the h-current in several animal models. While prior reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we recently found an upregulation of Ih in hyperexcitable CA1 pyramidal neuron dendrites following experimental febrile seizures. In addition, in several CA1 pyramidal neuron computational models of different complexity, h-current upregulation has been shown to lead to pro-excitable effects. This focused review examines the complex impact of altered h-current on neuronal resting membrane potential (RMP) and input resistance (Rin), as well as reported interactions with other ionic conductances.http://journal.frontiersin.org/Journal/10.3389/neuro.01.005.2009/fullacquired channelopathyEpilepsyexcitabilityh-current |
| spellingShingle | Jonas Dyhrfjeld-Johnsen Jonas Dyhrfjeld-Johnsen Robert J Morgan Ivan Soltesz Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy Frontiers in Neuroscience acquired channelopathy Epilepsy excitability h-current |
| title | Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy |
| title_full | Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy |
| title_fullStr | Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy |
| title_full_unstemmed | Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy |
| title_short | Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy |
| title_sort | double trouble potential for hyperexcitability following both channelopathic up and downregulation of i sub h sub in epilepsy |
| topic | acquired channelopathy Epilepsy excitability h-current |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.01.005.2009/full |
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