Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of I<sub>h</sub> in epilepsy
Studies of pathological ion channel regulation as an underlying mechanism of epilepsy have revealed alterations of the h-current in several animal models. While prior reports indicate that downregulation of the h-current is pro-excitatory on the single neuron level, we recently found an upregulation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2009-05-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.01.005.2009/full |