Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid
Anti-epileptic drugs can be associated with a wide spectrum of cutaneous adverse reactions ranging from simple maculopapular rashes to more severe and life threatening reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis. These rashes are well documented with older antiepileptic dr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=5;spage=406;epage=406;aulast=Kaur |
| _version_ | 1817969085514776576 |
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| author | Sukhjot Kaur Alka Dogra |
| author_facet | Sukhjot Kaur Alka Dogra |
| author_sort | Sukhjot Kaur |
| collection | DOAJ |
| description | Anti-epileptic drugs can be associated with a wide spectrum of cutaneous adverse reactions ranging from simple maculopapular rashes to more severe and life threatening reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis. These rashes are well documented with older antiepileptic drugs like phenytoin, phenobarbitone and carbamazapine. Lamotrigine is a newer, unrelated antiepileptic drug that causes skin rashes in 3-10% of new users. Higher starting dose or rapid escalation, concurrent treatment with valproic acid, and a previous history of a rash with other antiepileptic drugs are well recognized risk factors for lamotrigine related serious rashes. We report two patients with toxic epidermal necrolysis, resulting from concomitant use of lamotrigine and valproic acid. It is emphasized that clinicians adhere to the recommended dosage guidelines and adopt a slow dose titration when initiating treatment with lamotrigine. |
| first_indexed | 2024-04-13T20:16:57Z |
| format | Article |
| id | doaj.art-fa3b1d6076464d32b137cec9bbe4baef |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-04-13T20:16:57Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-fa3b1d6076464d32b137cec9bbe4baef2022-12-22T02:31:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112013-01-0158540640610.4103/0019-5154.117319Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acidSukhjot KaurAlka DograAnti-epileptic drugs can be associated with a wide spectrum of cutaneous adverse reactions ranging from simple maculopapular rashes to more severe and life threatening reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis. These rashes are well documented with older antiepileptic drugs like phenytoin, phenobarbitone and carbamazapine. Lamotrigine is a newer, unrelated antiepileptic drug that causes skin rashes in 3-10% of new users. Higher starting dose or rapid escalation, concurrent treatment with valproic acid, and a previous history of a rash with other antiepileptic drugs are well recognized risk factors for lamotrigine related serious rashes. We report two patients with toxic epidermal necrolysis, resulting from concomitant use of lamotrigine and valproic acid. It is emphasized that clinicians adhere to the recommended dosage guidelines and adopt a slow dose titration when initiating treatment with lamotrigine.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=5;spage=406;epage=406;aulast=KaurLamotriginetoxic epidermal necrolysisvalproic acid |
| spellingShingle | Sukhjot Kaur Alka Dogra Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid Indian Journal of Dermatology Lamotrigine toxic epidermal necrolysis valproic acid |
| title | Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid |
| title_full | Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid |
| title_fullStr | Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid |
| title_full_unstemmed | Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid |
| title_short | Toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid |
| title_sort | toxic epidermal necrolysis due to concomitant use of lamotrigine and valproic acid |
| topic | Lamotrigine toxic epidermal necrolysis valproic acid |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2013;volume=58;issue=5;spage=406;epage=406;aulast=Kaur |
| work_keys_str_mv | AT sukhjotkaur toxicepidermalnecrolysisduetoconcomitantuseoflamotrigineandvalproicacid AT alkadogra toxicepidermalnecrolysisduetoconcomitantuseoflamotrigineandvalproicacid |