TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis

TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis

A role for ferroptosis in articular cartilage destruction associated with rheumatoid arthritis (RA) has not been identified. We previously reported transient receptor potential melastatin 7 (TRPM7) expression was correlated with RA cartilage destruction. Herein, we further characterized a role for T...

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Bibliographic Details
Main Authors: Renpeng Zhou, Yong Chen, Shufang Li, Xin Wei, Weirong Hu, Su'an Tang, Jie Ding, Wanjin Fu, Hailin Zhang, Fan Chen, Wenjuan Hao, Yi Lin, Rendi Zhu, Ke Wang, Lei Dong, Yingjie Zhao, Xiaowen Feng, Feihu Chen, Changhai Ding, Wei Hu
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
Rheumatoid arthritis
Ferroptosis
TRPM7
PKCα
NOX4
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001835

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