Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver

Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components of glutathione, the major antioxidant in the li...

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Bibliographic Details
Main Authors: Eunsook S. Jin, Craig R. Malloy, Gaurav Sharma, Erin Finn, Kelly N.Z. Fuller, Yesenia Garcia Reyes, Mark A. Lovell, Sarkis C. Derderian, Jonathan A. Schoen, Thomas H. Inge, Melanie G. Cree
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Redox Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001507