Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity
Objective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four gr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-09-01
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| Series: | Asian Pacific Journal of Tropical Biomedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2221169115001586 |
| _version_ | 1811284639919112192 |
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| author | Farida Hussan Rina Haryani Osman Basah Mohd Rafizul Mohd Yusof Nur Aqilah Kamaruddin Faizah Othman |
| author_facet | Farida Hussan Rina Haryani Osman Basah Mohd Rafizul Mohd Yusof Nur Aqilah Kamaruddin Faizah Othman |
| author_sort | Farida Hussan |
| collection | DOAJ |
| description | Objective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity.
Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days.
Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine.
Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury. |
| first_indexed | 2024-04-13T02:32:38Z |
| format | Article |
| id | doaj.art-fa48758aa5b54d5f94494fd06780e967 |
| institution | Directory Open Access Journal |
| issn | 2221-1691 |
| language | English |
| last_indexed | 2024-04-13T02:32:38Z |
| publishDate | 2015-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Biomedicine |
| spelling | doaj.art-fa48758aa5b54d5f94494fd06780e9672022-12-22T03:06:31ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912015-09-015972873210.1016/j.apjtb.2015.06.013Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicityFarida HussanRina Haryani Osman BasahMohd Rafizul Mohd YusofNur Aqilah KamaruddinFaizah OthmanObjective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity. Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days. Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine. Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury.http://www.sciencedirect.com/science/article/pii/S2221169115001586Plantago majorAcetaminophenLiver injuryOxidative stressAntioxidants |
| spellingShingle | Farida Hussan Rina Haryani Osman Basah Mohd Rafizul Mohd Yusof Nur Aqilah Kamaruddin Faizah Othman Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity Asian Pacific Journal of Tropical Biomedicine Plantago major Acetaminophen Liver injury Oxidative stress Antioxidants |
| title | Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity |
| title_full | Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity |
| title_fullStr | Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity |
| title_full_unstemmed | Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity |
| title_short | Plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity |
| title_sort | plantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity |
| topic | Plantago major Acetaminophen Liver injury Oxidative stress Antioxidants |
| url | http://www.sciencedirect.com/science/article/pii/S2221169115001586 |
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